| Objective: The purpose of this research is to observe the clinical effect of Jianpixiaoyu Decoction in treating chronic atrophic gastritis with spleen deficiency and blood stasis,to further explore the mechanism of Jianpixiaoyu Decoction in the treatment of CAG,At last,I can find explore new methods for curing CAG.Methods:1.According to the accepted standard,selecting 60 patients from Shanxi University of Chinese Affiliated Hospital in Outpatient and ward,According to the random number table method,divided into the treatment group and the control group,30 persons per group.2.The treatment group was given Jianpixiaoyu Decoction,the water with 200 ml,sooner or later the service a day.The control group was given Weifuchun,4 tablets /times,oral 3 times a day,One treatment course was observed,which costed 3 months;then observed the two groups of patients before and after treatment symptoms,signs,gastroscope and pathology.3.Statistical analysis of all data using SPSS13.0 statistical software.Results:1.Comparison of TCM syndrome improvement:(1)The total effective rate of TCM syndromes in the two groups was 86.67% and 76.67%.Two groups of patients were statistically significant(P<0.05);(2)The total score of the two groups after treatment was statistically significant(P<0.01);(3)There was no significant difference between the two groups before treatment(P > 0.05).Treatment group and control group in addition to vomiting and loose stool water treatment,there was statistical significance over after treatment symptom score(P<0.05).The treatment group after treatment compared with before treatment vomiting water was statistically significant(P < 0.05),Loosestool had no statistical significance(P>0.05),other symptoms had significance(P<0.01).The control group before and after treatment,bloating,anorexia,belching,there was significant difference(P<0.01).Except loosestool,other symptoms had significance(P < 0.05).The treatment group ofepigastric pain,fatigue,noise is better than the control group.2.Pathological score improvement:(1)Gastric mucosal atrophy score improvement:After treatment,the treatment group and control group gastric mucosal atrophy score was statistically significant(P < 0.05),There was significant difference in the treatment group before and after treatment(P < 0.01);The control group had statistical significance before and after treatment(P<0.05).The results showed that the gastric mucosal atrophy in the treatment group was significantly better than that in the control group.(2)Intestinal metaplasia of gastric mucosa: After treatment,the treatment group and the control group gastric mucosa intestinal metaplasia score was statistically significant(P<0.01);There was significant difference in the treatment group before and after treatment(P < 0.01);The control group had statistical significance before and after treatment(P < 0.05);It showed that the intestinal metaplasia of gastric mucosa in the treatment group was significantly better than that in the control group.3.Pathological effect improvement:(1)Gastric mucosal atrophy's curative effect:After treatment,the treatment group gastric mucosal atrophy clinical efficiency of76.67%,the control group of gastric mucosal atrophy clinical efficiency of 63.33%,the patients in the two groups were statistically significant(P=0.004),The effect of the treatment group was better than that of the control group;(2)Effect of intestinal metaplasia in gastric mucosa: After treatment,the clinical efficacy of gastric mucosa intestinal metaplasia was 66.67% in the treatment group and the control group was significantly higher than that in the control group.The clinical effective rate of the control group was 62.50%,and the difference between the two groups was statistically significant(P=0.037),The effect of the treatment group was better than that of the control group.4.Two groups of patients with gastric mucosal atrophy degree of comparison,after treatment,the treatment group and the control group was statistically significant(P=0.042),the treatment group was statistically significant(P=0.002);There was no significant difference in the control group;The effect of the treatment group was better than that of the control group.Two groups of patients with gastric mucosaintestinal metaplasia degree comparison,after treatment,there was a statistically significant difference between the groups(P=0.046),the treatment group was statistically significant(P=0.030),there was no significant difference in the control group(P>0.05);the effect of the treatment group was better than that of the control group.5.Safety index: There was no obvious adverse reaction between the two groups before and after treatment.Conclusions:1.Compared with the control group,the treatment group can effectively improve the total effective rate of TCM syndrome.2.After treatment,the total score of TCM syndrome in the treatment group was statistically significant compared with the control group.The treatment group was better than the control group in improving TCM syndrome.3.The treatment group in improving patients with spleen deficiency and blood stasis syndrome,such as epigastric pain,bloating,fatigue,anorexia,belching,a syndrome of traditional Chinese medicine have obvious curative effect.Epigastric pain,fatigue,noisy symptoms better than the control group.The treatment group can improve CAG patients with spleen deficiency and blood stasis syndrome.4.The two groups were able to improve gastric mucosal atrophy and intestinal metaplasia in patients with CAG,while the treatment group was better than the control group in improving gastric mucosal atrophy and intestinal metaplasia.5.The treatment group gastric atrophy,intestinal metaplasia clinical efficiency is better than the control group6.Two groups of patients with atrophy of gastric mucosa grade,after treatment between the two groups was statistically significant(P=0.042);two patients with intestinal metaplasia in gastric mucosa grading comparison,comparison between the two groups after treatment was statistically significant(P=0.046);the effect of the treatment group than the control group.7.After the end of treatment,patients with hematuria and routine liver and kidney function were not abnormal,the patient did not have allergies,indicating that thetreatment group is safe and effective in the treatment of patients with CAG.Through the clinical observation,the treatment group can effectively improve the symptoms,signs and pathological state of the CAG spleen deficiency and blood stasis syndrome.There was no obvious abnormality in the clinical trial.Studies have shown that the spleen and Blood Stasis Decoction can play a role in enhancing immunity,anti-tumor,promote gastric motility,improve,protect the gastric mucosa,such as the role of pathogenic microorganisms,it is worth further clinical research. |
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