Change Of Sos1/2Protein In Expression In Non-Infarcted Myocardium In Rats

Objective：To investigate the change of Sos (Son of Sevenless)1/2proteinexpression in non-infarcted myocardium in rats. Methods：Experimentalmyocardial infarction (MI) and sham-operation (sham) models in SD ratswere established respectively. Sos1/2protein expression in non-infarctedmyocardium in the MI group and in myocardium in the sham group wasmeasured by Western blot respectively. Results：Sos1/2protein expressionin the non-infarcted myocardium in the MI group（0.40±0.13, n=8）at12weeks after infarction was significantly higher as compared with that in themyocardium in the sham group （0.24±0.08, n=8）at12weeks afteroperation, in the non-infarcted myocardium in the MI group （0.25±0.10,n=8）at24h after infarction and in the myocardium in the sham group（0.26±0.11, n=8） at24h after operation respectively (All P＜0.05).Conclusion： There exists Sos1/2protein expression in themyocardium in rats. Sos1/2protein expression is significantly increased inthe non-infarcted myocardium after infarction. The increased Sos1/2protein expression could be involved in the post-infarction left ventricularremodeling.