Study Of The Relationship Among Ankle-Brachial Index With Carotid Artery Stenosis And Risk Factors In Patients Of Cerebral Infarction

Objective: To investigate the correlation between ankle-brachial index(ABI) and thedegree of carotid artery stenosis, and to evaluate the correlation between risk factorsof cerebral infarction and carotid arterial stenosis, and to evaluate the correlationbetween ABI and recent cardiac and cerebrovascular incidents.Methods: Continuous collection of268Cerebral Infarction cases betweenDecember2010and June2011in the First People’s Hospital of Chenzhou. Allpatients went through detailed nervous system physical examination and relatedlaboratory tests: fasting blood glucose, and lipid, and blood General, and liver kidneyfunction, and electrolytic mass, and blood with type half cysteine (HCY), and supersensitive c reaction protein (CRP), and and perfect heart color Super, and ECG, andVascular Doppler ultrasonography and neck and ankle and brachial artery bloodpressure measurements on the same side. Secondary checks were also included:inquired about patients’ general condition such as age, sex, height, body mass index,smoking and drinking history, and past medical history: history of hypertension,diabetes mellitus, lipid metabolism disorders, history of cerebrovascular and coronaryheart disease history. Followed the patients up to six months after ABI self test, andevaluate the prognosis of patients through recording cardio-cerebral-vascular eventswithin the sixth months. Classification standard of reference to the North Americansymptomatic carotid artery stenosis underwent carotid endarterectomy experimentalstandard and Chinese society of Radiology in ultrasound on carotid atheroscleroticstenosis of the world (CAS) into ⅰ~ⅳultrasonic grading standards, and define: grade ⅰ non-narrow group, II~VI to a narrow group, a narrow set of124cases, nota narrow set of144cases. ABI is bounded by0.9hierarchies, ABI≤0.9to theexception group, ABI﹥0.9is set to normal,59cases of exception group,209casesof patients with normal group. SPSS17.0statistical analysis software, comparison ofmeasurement data using analysis of variance, analysis of count data using Chi squaretest.Results:1. ABI was negatively correlated with CAS (r=-0.894,0.01). The moreserious in CAS grading, the lower value of average of ABI in patients. CASclassification of group differences in ABI was different. ABI grading between thegroups have significant differences (p﹤0.05).2. ABI normal group and exception group were significantly different in diabetes,and hypertension disease, and fasting blood glucose, and low density fat protein, andtotal cholesterol, and glycerol three ester level (p﹤0.05). The result of multivariateLogistic gradually regression equation shows: lipid of exception (total cholesterol,and low density fat protein, and glycerol three ester of rise) was exceptionalindependent risk factors of ABI.3.There were no significant differences between Non-narrow and narrow CASgroup in significant in the history of the history of smoking, diabetes, high bloodpressure, fasting blood glucose, LDL-C, ABI (p﹤0.05). The result of multivariateLogistic regression analysis showed: smoking, diabetes, ABI, LDL-C were theindependent risk factors for carotid artery stenosis.4. Among the follow-up of6months, cardiovascular and cerebrovascular eventsoccurred in52cases (cerebral stroke or transient ischemic attack). cardiovascularevents (myocardial infarction or angina pectoris)21. To follow-up six months Shi isoccurs heart brain vascular event for prognosis detection index, and as due to variable,to age, and gender, and hypertension, and diabetes, and coronary heart disease, andABI value, and drinking, and smoking as may of forecast factors index, and as sincevariable, line more factors Logistic regression analysis, results shows ABI value andhypertension disease (HBP) into people equation, equation for P=1/［e－(－ 1.113HBP+10.862ABI－8.647)］。Conclusion:1. Negative correlation was found between ABI and the degree of CAS.2. Dyslipidemia and particularly LDL-C are exceptional independent risk factors ofABI.3. LDL-C, ABI,smoking, are independent of carotid artery stenosis.4. In patients with cerebral infarction, ABI is independent risk factors ofcardiovascular and cerebrovascular events in the near future.