The Relations Of RECK Gene With Non-small Cell Lung Matrix Metalloproteinase And Its Invasion And Metastasis

Abstract Objective: To study the expression and correlation of RECK、MT1-MMP andTIMP-2in Non-Small-Cell Lung Cancer (NSCLC))and clinic pathological features.Methods: Immunohistochemical SP method was used to detect the expression of RECKand MT1-MMP、TIMP-2proteins in80NSCLC tissues and80para-cancerous tissues.Results: The positive expression of RECK proteins in NSCLC carcinoma tissues was36.3%lower than that81.3%in para-cancerous tissues.The positive expression ofMT1-MMP in NSCLC carcinoma tissues was73.8%higher than that52.5%inpara-cancerous tissues. The positive expression of TIMP-2in NSCLC carcinoma tissueswas42.5%lower than that72.5%in para-cancerous tissues. RECK-expression in cancertissue was correlated with histological types and grades.Positive expression ofMT1-MMP and TIMP-2were correlated with lymph node metastasis and TNM stage,but no relationship with pathology subtype and histological grades. The expressionsbetween RECK and MT1-MMP were presented negative correlation.The expressionsbetween RECK and TIMP-2were no significant correlation. The expressions betweenMT1-MMP and TIMP-2were presented negative correlation（r=-0.635，P＜0.05）.Multivariable logisitic regression analysis found that low expression of RECKproteinwas the poor prognosis factor.Conclusion: The expression of RECK and MT1-MMP have some correlations inNSCLC.The expression of RECK,MT1-MMP and TIMP-2may take part in theprogress of NSCLC.RECK gene and MT1-MMP may be the indexs to predict thebiological behaviour and prognosis of NSCLC patients.