Experimental Study On Mri-guided High Intensity Focused Ultrasound Ablation Of The Left Adrenal Gland In Dogs

Objective The aim of this study was to evaluate the feasibility of highintensity focused ultrasound (HIFU) ablation of the left adrenal gland indogs guided by magnetic resonance imaging (MRI).Methods16healthy mongrel dogs, weighing9-13Kg, establishedhyperplasia model by the injection of ACTH1-24， were receivedMRI-guided extracorporeal HIFU ablation of the left adrenal gland. Afterablation, enhanced MRI was used to evaluate the damage of the adrenal andadjacent organs and tissues. All dogs were executed5days latter，thedestruction of the left adrenal gland and adjacent organs were observed. Theablation of adrenal gland was assessed with the hematoxylin and eosin (H&E)staining.Result After ablation, all cases of dog vital signs were stable. EnhancedMRI showed a significant signal decrease in the ablation regions of adrenaland no obvious abnormal signals in the adjacent organs. The ablation lesionsin the head and tail of the left adrenal can be seen clearly. HE stainingshowed ablation lesions of adrenal had pathological necrosis and a clear demarcation between the surrounding tissues.Conclusion MRI guided HIFU is a safe and effective method toobtain controllable ablation of adrenal, and HIFU technique may haspotential usage in the minimally invasive treatment adrenal diseases.