The Medthod Of Dispersing The Depressed Liver-energy And Benefiting The Spleen And Detoxify Have A Clinical Study Of The Effect Of IFN-γ On Chronic Virus B Hepatitis(Stagnation Of Liver-Qi With Deficiency Of The Spleen-Qi Accompany With Damp-heat Syndrom

Objective:The medthod of dispersing the depressed liver-energy and benefiting the spleen and detoxify have a clinical study of the effect of IFN-yon chronic virus B hepatitis (Stagnation of liver-Qi with deficiency of the spleen-Qi accompany with damp-heat syndrome).Observation a study on the serum level of IFN-γ.To explore its mechanism.Methods:All the Patien comes from the first affiliated Heilongjiang University Of Chinese Medicine from January2010to May2011. Patients with hepatitis B come from the liver and spleen stomach disease of outpatient. In strict accordance with the inclusion criteria. We selected60cases of patients. They were divided into control group and treatment group at random. Each group was30patients,Normal control group was30cases. The treatment group takes Gan Ning granule in treating composition. The control group received hepatitis B Qingre capsules. The course of treatment is3months, the change of some coditions of patients were observed before and after treatment as follows:clinical efficacy, mainly to improve the situation TCM Syndrome, liver function and zhe spleen, hepatitis B virus markers, Interferon gamma. The establishment of database, Spss17.0statistical software packages used statistical data analysis, Counting material use X2insPeetion, Measuring material t-test.Conclusion:1. The overall clinical effeets of two group, treatment group, the totale ffeetive rate was93.33%.control group, the totale ffeetive rate was66.66%. The overall clinical efficacy of the two groups showed significant difference (p<0.05).2. The groups of Chinese medicine after treatment than befor the syndrome had improved(P<0.01), we comparison of the treatment group with control group had no significant difference (P>0.05).3. In improve liver inflammatory activities, lier inflammation after treatment,treatment group get a different degree of recoverywill, have significant difference(P<0.05). Comparison of the twogroups, Two groups doot have significant difference(P>0.05).4. The overall level of gamma interferon in patients with chronic hepatitis B were lower than the normal group. the two groups showedsignificant difference (p<0.01).5. Treatment group can decreaseHBV-DNA quantitative, Two groups showed significant difference (p<0.05).6. Treatment groups after the treatment, levels of IFN-ywere elevated, The comparison of the treatment group with control group had sig nificant difference (P<0.05).7. Patients withHBV-DNA load and serum IFN-gamma levels negatively correlated (P<0.05).Conclusion:The medthod of dispersing the depressed liver-energy and benefiting the spleen and detoxify treatment of chronichepatitis (Stagnation of liver-Qi with deficiency of the spleen-Qi accompany with damp-heat syndrome). Symptom was improved. lier inflammation after treatment, get a different degree of recovery will. It can kill virus. This method can improve the levelof IFN-γ. It can mobilize the immune factor level, So it can improve the efficacy of treatmenting.