Expression And Signifcance Of CtBP2in Prostate Cancer

Objective:1. Determine the expression level of CtBP2in prostate cancer tissues and benign prostatic hyperplasia tissues;2. To evaluate its relation with clinicopathologic significance.Methods:A total of119prostate cancer samples were obtained during surgery from patients with prostate cancers diagnosed by pathologically at the Second Hospital of Tianjin Medical University between January2005and September2011. Benign prostatic hyperplasia tissues were collected as control from41during the same time. All the tissues were examined pathologically to exclude the possibility of incidental tumors. Total RNA extraction and cDNA synthesis by qPCR, western blot techniques to analyze the level of CtBP2expression in prostate cancer and benign prostatic hyperplasia tissue, and to determine the relationship of clinical and pathological parameters associated with prostate cancerResults:1. CtBP2expression in prostate cancer tissue was significantly higher than the adjacent normal tissue and benign prostatic hyperplasia.2. The CtBP2over-expression were correlated with the serum prostate specific antigen (PSA)(p=0.018), high levels of tumor stage (T3)(P=0.025), higher Gleason score (P=0.019), seminal vesicle invasion (P=0.007), positive lymph nodes (P=0.018),vascular invasion (P=0.01) and perineural invasion (P=0.035).3. CtBP2over-expression have no significant association with the patient’s age (P=0.776) and positive surgical margin (P=0.521).4.CtBP2over-expression was signifantly associated with the poor prognosis of prostate cancer patients.Conclusion:1. CtBP2over-expression in prostate cancer tissue was significantly higher than the benign prostatic hyperplasia tissue.2.CtBP2over-expression closely associates with the tumorigenesis and progression of prostate cancer.3. CtBP2over-expression may have some reference value for the diagnosis of prostate cancer, and may become a potential target for treatment of prostate cancer.but also need to be futher studied.