| Objective: To observe the clinical efficacy of Danhong injection of blood stasis in patients with coronary artery disease after PCI myocardial ischemia reperfusion injury.Methods:80cases met the inclusion criteria after PCI with coronary heart disease patients were randomly divided into treatment group (treatment on the basis of conventional western medicine plus Danhong injection30mL+0.9%normal saline250mL intravenous infusion) and control group (conventional Western medicine treatment), all40cases. Clinical efficacy of an eight-day, while at the time of admission, on postoperative day1, one week after surgery were measured troponin I and creatine kinase isoenzyme (CK-MB), high-sensitivity C-reactive protein (Hs-CRP), amino front of brain natriuretic peptide (NT-proBNP) levels, and record the patients on admission, PCI postoperative lh-3h within the chest pain and ECG24hours after PCI Record reperfusion injury caused by arrhythmia.Results:①The two groups after treatment, NT-proBNP values than those before treatment was significantly lower (P<0.001), and the treatment group than the control group decreased significantly (P<0.05);(2) Hs-CRP values compared with pre-treatment significantly reduced (P <0.05), and the treatment group than in the control group were significantly lower (P<0.05);③The troponin I and creatine kinase isoenzyme (CK-MB) value than that before treatment was significantly lower (P<0.01) and the treatment group than in the control group decreased significantly (P<0.05); eased significantly (P<0.001)(4) symptoms of chest pain than before treatment, the treatment group than the control group to ease significantly (P <0.05);⑤The two groups preoperative arrhythmias are not statistics, after PCI (included), the control group, arrhythmias was55%(including the fast type of arrhythmia was47.5%, arrhythmias was7.5%), treatment group The Tachyarrhythmias32.5%(25%incidence of arrhythmias was7.5%), incidence of arrhythmia treatment group than the control group (P<0.05). And the control group and treatment group in Tachyarrhythmias (P<0.05), prompted a statistically significant difference.Conclusion: The blood stasis of coronary heart disease after PCI myocardial ischemia and reperfusion injury in patients, through the addition of Danhong injection after treatment, the improvement of the symptoms of heart function, reduce myocardial injury, the inhibition of the inflammatory response to reperfusion arrhythmia incidence reduction, relief of symptoms of chest pain than the control group. The drug in the clinical course of medication adverse reactions, its safe and reliable and can provide a reference for clinical drug prevention efforts stasis type in patients with coronary heart disease after PCI-induced myocardial ischemia and reperfusion injury. |
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