Expression And Clinical Significance Of NM23and Survivin In Colorectal Cancer

Background and Purpose:Colorectal cancer is one of the most common malignant gastrointestinal tumors,which’s incidence is more and more high. Although surgery and adjuvant therapy continueto improve, the overall mortality of colorectal cancer in recent years, did not significantlyreduce, and caused great harm to human health. Therefore, the discussion of development,invasion and metastasis mechanisms in colorectal cancer can establish the theoretical basisfor guiding clinical diagnosis, giving timely and relevant intervention to improve patientsurvival, prognosis, and providing direction for the development of anticancer drugs. Inthis discussion,we will explore the relationship of Survivin and NM23in occurrence anddevelopment,infiltration and metastasis of colorectal cancer.Methods:From January2010to April2011, in Jinan Fourth People’s Hospital, a total of90cases of colorectal cancer specimens resected and pathologically confirmed, and providedwith complete clinical and pathological data were collected. At that time, the experimentcollected30cases of normal intestinal mucosa,10cm far away from colorectal carcinoma.All colorectal cancer specimens did not receive any radiotherapy, chemotherapy and othertreatments before surgery. Immunohistochemical method was used to investigate theexpression of Survivin and NM23.Results:①In30normal colorectal mucosa, there was no positive expression of Survivn in the30cases,but positive expression of NM23in28cases.②In90cases of colorectal cancer, the positive expression rate of NM23protein was36.7%(33/90),which was significantly lower compared to that in normal colorectalmucosa (93.3%28/30P<0.05).The positive expression rate of Survivin protein was66.7%(60/90) in colorectal cancer, significantly higher than the percentage of Survivin-positivecase obtained from normal colorectal mucosa(0%0/30P <0.05). ③The positive expression of Survivin in colorectal cancer was significantlycorrelated with the degree of histological differentiation,depth of invasion, lymph nodemetastasis (P=0.000,P=0.018,P=0.005).Expression of NM23expression was significantlyassociated with depth of invasion and lymph node metastasis (P <0.05).④The correlation analysis showed that: there was the negative correlation betweenNM23expression and the expression of Survivin in colorectal cancer (r=-0.636,p=0.000).Conclusion:l.The expression of Survivin in colorectal cancer significantly increased,NM23expression in colorectal cancer significantly reduced, which indicates that they play animportant role in occurrence, development, invasion and metastasis in colorectal cancer.2.The expression of Survivin and NM23in colorectal cancer was significantlycorrelated with clinicopathological features, therefore their expression can be used asindicators for the degree of malignancy of colorectal cancer.3.The correlation analysis showed that: there is the negative correlation betweenNM23expression and the expression of Survivin in colorectal cancer,which indicates thatthere is a opposite effect between them in regulatory mechanisms and means of promotingcell proliferation,inhibiting apoptosis and promoting tumor cell migration,invasion,metastasis.4.The combined detection of these two kinds of protein expression levels, is of greatvalue to assess the biological behavior of colorectal cancer,to help assess the prognosis ofpatients,provide clinical treatment basis,and they may become new molecular targetedtherapy sites of the colorectal cancer.