Prevention And Treatment Of Certain Kind Of Cephalosporins Dust With Strong Allergenicity

7-aminocephalosporanic acid (7-ACA) is the key intermediates of cephalosporin, withstrong allergenicity and very serious impact on workers and the environment. ZhongrunPharmaceutical of Shijiazhuang Pharmaceutical Group ranks the first in7-ACA quantities ofChina, and the clean and safe production of enterprise plays a pivotal role in the healthydevelopment of the cephalosporins. Combined with the dust status quo of productionworkshop, the prevention technology about7-ACA drugs dust are researched to developtargeted prevention programs. It provides the necessary theoretical and technical support tocomprehensive treatment project of7-ACA dust in Zhongrun Pharmaceutical.The comparative study of hazard rating and classification about drug dust control isimplimented. And the management basis of this dust is cleared. Combined with7-ACAproduction process, the key of producing dust point and producing dust reasons are identifed,and the producing dust causes and existing defects of dust prevention countermeasures arefound out. Many process equipment are modified, which make drying, sifting, packagingequipment and powder delivery production process airtight, so the drugs dust is controlledfrom the source. The ventilation system and dust removal device are transformed, the airfloworganization is optimized. The workshop ventilation, send from side and back from the lowerside, is used. The original baghouse is converted to the cartridge filter. The individualprotection is strengthened. The standard of protective respirators equipped with in highsensitization dust post is determined and the filter cotton with high filtration efficiency is used,which decrease the dust concentration to less than0.001mg/m~3.The research has important guiding significance to the7-ACA drug dust prevention andcontrol work. And it provides the technical reference for the same industry and similarenterprises.