Clinical Survey Of The Xi-shiyin In Treatment Of Non-proliferative Diabetic Retinopathy

Objective:To evaluate the efficacy and safty of the Xi-shiyin in treatment of non-prolifcrative diabetic retinopathy (NPDR).Methods:Designing randomized clinical trail. The study included71patients who complied with the standard:34cases were regarded as Xi-shiyin group,33cases as control group. Experimental observation time was25weeks, including1-week washout period,12-week treatment period and12-week follow-up period. On the basis of life-style intervention,Xi-shiyin group and the control group had received Xi-shiyin,10ml, three times a day for12weeks. Compare with the level of blood glucose, blood lipids in each group after treatment, ophthalmic examinations with fundus photography, symptom of TCM. To evaluate the drug safety.2358925Results:(1) The study included71patients with a expulsion rate of5.6%., of which67patients completed the clinical trial, the treatment group lost the two cases, the control group off the two cases.(2) After12-week treatment, glycosylated hemoglobin level of the treatment group were reduced significantly than before(P<0.05).(3) Analysis according to ITT.the total effective rate in Xi-shiyin group is80.56%, The total effective rate in the controlled group is31.43%. Analysis according to PP,the total effective rate in Xi-shiyin group is85.29%, The total effective rate in the controlled group is33.33%.(4) After12-week treatment12-week of follow-up, adverse events were not observed in either groups.