The Research Of Correlation Of Bone Metabolism And Blood Stasis Of Perimenopausal Women Frome The Estrogen Levels To Explore

Objective:Detection estrogen and bone metabolic markers of perimenopausal women at different stages, and an objective evaluation of the "Blood stasis" from a macro perspective, using multiple regression statistical analysis, from the level of estrogen explore perimenopausal women bone metabolic status and "blood stasis" correlation.Methods:132perimenopausal women met the inclusion criteria was divided into four groups by every five years old. The bone metabolic markers including the amino acids middle of osteocalcin(NMID), I procollagen amino-propeptide (PINP), I carboxy-terminal peptide(β-crosslaps,CTX) and the estradiol (E2) was tested by the electric enzyme-linked immunosorb-ent assay. At the same time, the standard of blood stasis quantitative score, the weighted score of the nail fold microcirculation of Tian Niu and hemorheology was detected. At last, the correlation of the weighted score of the nail fold microcirculation, the blood stasis quantitative score, hemorheology, NMID,PINP,CTX and E2was analyzed by using multiple regression statistical analysis.Results:(1)There was a low negative correlation among E2and blood stasis quantitative score, N-MID,CTX. The rank correlation coefficients were-0.259,-0.376,-0.275, and P<0.01; There was a middle negative correlation among E2and nail fold microcirculation, PINP. The rank correlation coefficients were-0.424,-0.434, and P<0.01.(2)There was a low negative correlation among E2concentration and high shear blood viscosity, low shear blood viscosity, high shear blood reduced viscosity, middle blood shear reduced viscosity,low blood reduced viscosity, erythrocyte rigidity index. The rank correlation coefficients were-0.335,-0.237,-0.207,-0.200,-0.300,-0.238, and P<0.05;There was a middle negative correlation between E2and middle shear blood viscosity. The rank correlation coefficients was-0.409, and P<0.01;There was a low positive correlation between E2and erythrocyte electrophoresis time. The rank correlation coefficient was0.282,and P<0.01(3)There was a low positive correlation between blood stasis quantitative score and nail fold microcirculation. The linear correlation coefficient was0.368, and P<0.01.(4)There was a low positive correlation among nail fold microcirculation and low shear blood viscosity, high shear blood reduced viscosity, middle blood shear reduced viscosity, low blood reduced viscosity. The linear correlation coefficients were0.227,0.249,0.289,0.372, and P<0.01;There was a middle positive correlation among nail fold microcirculation and high shear blood viscosity, middle shear blood viscosity, erythrocyte rigidity index. The linear correlation coefficients were0.429,0.580,0.406, and P<0.01; There was a low negative correlation between nail fold microcirculation and erythrocyte electrophoresis time. The linear correlation coefficient was-0.309, and P<0.01.(5) There was a low positive correlation among NMID and middle shear blood viscosity, blood stasis quantitative score. The linear correlation coefficients were0.257,0.280, and P<0.01.(6) There was a low positive correlation among PINP and middle shear blood viscosity, blood stasis quantitative score. The linear correlation coefficients were0.248,0.320, and P<0.01;There was a middle positive correlation between PINP and nail fold microcirculation. The linear correlation coefficient was0.419, and P<0.01.(7) There was a low positive correlation among CTX and blood stasis quantitative score, nail fold microcirculation. The rank correlation coefficients were0.282,0.238, and P<0.01. There was a low negative correlation between CTX and erythrocyte electrophoresis time. The rank correlation coefficient was-0.226,and P<0.01.Conclusions:Estrogen levels and bone turnover in perimenopausal women was closely related,a positive correlation with bone formation and a negative correlation with bone resorption, estr-ogen levels and expression of blood stasis in perimenopausal women were negatively correlation, blood stasis and bone turnover in perimenopausal women was closely related,and blood stasis was one of the factors in perimenopausal women with the change of bone metabolic status and the acceleration of bone turnover.