Teacher Professor He Juqiao will observe the psoriasis course of an illness in the course of time, repeatedly manifests suddenly, displays expands for the skin rash, the skin damages the accumulation. its pathology characteristic are many hotly for the blood cloudyly consumes, the blood stasis stagnation of flow of vital energy, poisonously stagnates the passages through which vital energy circulates, the stasis anti-channels and collaterals is the result of. Huoxuexiaoyin piece is teacher near the card more than 30 years clinical experience summary.And in the clinical practice discovered has the good treatment function to the blood stasis psoriasis patient.It possessed the effect of activing and nourishing blood,clearing away heat and toxic material.This topic is for the purpose of discussing the treatment blood stasis psoriasis the pathogenesis, as well as invigorates the blood to disappear the blood stasis syndrome of psoriasis treatment mechanism. Before and after treatment,60 suffers involed were asked to fill in PASI (psoriasis area end severity index) in order to know clinical curative effect. At the same time, hemorrheology, blood platelet index,nail fold capillary circulation, endothelial growth factors in suferers’serum also be investigated. And stochastically extracts 10 examples with Huoxuexiaoyin piece treatment psoriasis patient, the expression of VEGFmRNA, collagen typeⅠ,micro-vascular density in sufferers’lesions sample were examined respectively by the means of insituhybridization(ISH) and immunohistochemistry (IHC).Also carries on the contrast with the normal person. The result showed as follow:1. Huoxuexiaoyin piece can reduce sufferers’scores of PASI, was proved to have a secure and Effective on treating blood stasis syndrome of psoriasis;2. The blood stasis syndrome of psoriasis’micro-circulation change and the normal person form the remarkable difference, Huoxuexiaoyin piece be able to treats this sickness through change micro-circulation of blood stasis psoriasis;3. The blood stasis syndrome of psoriasis’blood vessel proliferation change and the normal person form the remarkable difference, Huoxuexiaoyin piece be able to treats this sickness through delaying epidermis multiplication of blood stasis psoriasis.We result suggested that Huoxuexiaoyin piece can improve the clinical symptom of blood stasis syndrome of psoriasis, through changing microcirculation and delaying epidermis multiplication. |