Bone Mineral Density And Pathologic Study Of Osteoporotic Vertebral Compression Fracture

Objective:To investigate bone mineral density rage and pathological features in the periods of osteoporotic vertebral compression fractures, and verify the consistency of bone mineral density and pathology.Background:Is vertebral compression fractures caused by osteoporosis potential pathological development process. Clinical commonly used determination of bone mineral density and vertebral body bone tissue specimen pathology change to evaluate the occurrence, development and evolution process of osteoporosis. For osteoporosis research at home and abroad is still a hot spot, mainly observed the pathological process of development of osteoporosis and the biomechanics of vertebral osteoporosis occurs change. Bone mineral density as a condition of judgment criteria of osteoporosis has been widely used in clinical disease diagnosis, but its value of the vertebral body fractures themselves pathological change characteristic is rarely.Material and method:According to different age of45cases of imaging findings for osteoporotic vertebral compression fractures cases are grouped, on the dominant side in PKP holds the preoperative proximal femur (T) values and (density value of detection. While the conventional X-ray, CT, MR imaging examination, eliminate surgical contraindications, and then give the percutaneous puncture of the protruding after keratoplasty, vertebral bodies in intraoperative conventional bone specimen and living tissue removed in decalcified, dyeing and pathological observation. The consistency between the range of BMD in different age and compression failure on pathology and the predictive value of BMD for diagnosing osteoporosis compression fractures were analyzed.Result:On preoperative bone mineral density range value determination of various age groups of visible high age group (60-69age group, and70-79age group, and70aged group) in the vertebral bone mineral density value is significantly lower than the low age group (group50to59years old), and gradually reduce the trend of increase, a significant negative correlation between. The pathological findings:decreased bone mineral density, trabecular thinning, sparse, and the number reduced interval widened, arranged in irregular, or necrosis; surrounded by fibrous tissue proliferation, and reactive new bone formation in the latter. Statistical indicators according to the P<0.05to determine the significant contrast between various factors has the significance. The average lumbar BMD value exist significant differences between age groups (P<0.05), and (density lower than proximal femur is more apparent. Which60-69age group of men and women in the gender composition of fracture than the obvious difference, the other the probability of fracture is no significant difference between age groups (P>0.05), and may be associated with patient’s physical condition, activity, etc. BMD decline consistent correlation with pathological fracture performance of process, the results show that the bone osteoporotic vertebral fracture destruction pathology staging is a gradual development process, and reduced bone mineral density can reflect the compression of the vertebral body damage.Conclusion:Patients with different age stages of their lumbar spine and proximal femur bone mineral density in the vertebral bodies and gradually reduce with the increase of age, the biomechanics of vertebral bodies performance in constant change, it can withstand the compressive stress is also gradually decline, the changes in the microstructure of bone tissue, from down to the bone trabecular, and bone metabolism was accelerated. As the vertebral bone mineral density decreased, vertebral body bone destruction unceasingly, the vertebral body compression failure is a progressive pathological process.