Yiqi Strong Heart Drink For Chronic Heart Failure Rats Serum Bnp Level And The Influence Of Cardiac Function

Purpose： This experiment by animal experiments to establish chronic heartfailure in the rat model, to observe the influence of the BNP level and cardiacfunction that the Chinese medicine YiQi Strong Heart Liquid Medicine cure CHFrats. From serology and heart structure in research of traditional Chinesemedicine YiQi Strong Heart Liquid Medicine to chronic heart failure Yang syndromeof the intervention mechanism and function.Material and method：Under build up CHF rat medol, we random divided ratinto4setses,including a false surgical operation set, model set, Chineseherbal medicine set and western medicine matched control, each set have10rats,after using a medicine for8weeks, observe the general appearance, BNP level,the heart function.Results：1.Succeed to build up CHF Yang deficiency inundation rat model.2. Scores group’s LVIDd increased obviously,compared with the blank group(P <0.01), significant statistically difference; After the intervention bythe drugs,Traditional Chinese medicine groups and western medicine groups ofLVIDd decreased, two groups compared with model groups (P <0.01), significantstatistically difference; Traditional Chinese medicine group’s LVIDd comparedwestern medicine group’s LVIDd P>0.05,the differences was not statisticallysignificant.3. Scores group’s FS was significantly lower, compared with the blank group(P＜0.01), significant statistically differences; After the intervention bythe drugs, the traditional Chinese medicine group and western medicine group’sFS were significantly increased (compared with model group,P＜0.01),statistically significant difference; Chinese medicine group compared withwestern medicine group, P>0.05, the differences was not statistically significant.4. Scores group’s BNP was significantly heighten, compared with the blankgroup (P＜0.01), significant statistically differences; After the interventionby the drugs, the traditional Chinese medicine group and western medicinegroup’s BNP reduced significantly (compared with model group,P＜0.05), it wasstatistically significant differences; traditional Chinese medicine groupscompared with western medicine groups P>0.05, the differences were notstatistically significant.Conclusion：1、Application erode the abdominal aorta method combined with corticosteroidsmade mode method to establish the chronic heart failure Yang deficiencyinundation rat model, through the serum brain natriuretic element, ultrasoundand rats behavior change modeling methods that made feasible, and can be usedin the research of chronic heart failure.2、YiQi Strong Heart Liquid could obviously improve the chronic heart failurerat’ssymptom, and cardiac functions, decrease the general condition of chronicheart failure rat’s BNP levels of serum, delaying ventricular remodeling.3. YiQi Strong Heart Liquid Medicine was proved that it’s safe, practical andeffective, curative effect equate the western medicine control groups.4.Invigorating Qi, warming Yang, activating blood, rickey,Traditional Chinesemedicine yiqi strong heart Liquid to chronic heart failure Yang the card canhave water prevention and treatment for heart failure and delay the developmentof heart failure functions.