Ge Stilbene Hypoglycemic Granule On Diabetic Peripheral Neuropathy Clinical Research Of Active Influence

Diabetic peripheral neuropathy of diabetes has become the main cause of disability.The incidence rate is up to60%-90%.At present, the pathogenesis of DPN is not clear.It may be caused by multiple factors, Including vascular risk factors for metabolic disorders, autoimmune factors,and genetic factors. In clinical treatment.it is lack of effective treatment.Polyol pathway activity at present is a new hotspot in the pathogenesis. But as a key mechanism in the field of peripheral neuropathy in diabetes, its study was just a little. According to academician Wang Yongyan proposed "toxin damaging brain collaterals" theory and combined with clinical observation,Mentor professor Lou Xien put forward "deficiency of kidney and blood stasis,poison damage context" is the basic pathogenesis of diabetic peripheral neuropathy and made the " Jie du Huo xue,early intervention of Yi qi Bu shen ", had a good curative effect in clinic.Objective:Observe the changes of symptoms and signs of Ge Jiang tang Granule on peripheral neuropathy in type2diabetes mellitus (DPN) patients before and after treatment;Monitoring of blood glucose, glycosylated hemoglobin (HbA1c), aldose reductase (AR) activity. To explore the clinical significance of geqi Jiangtang particles as AR inhibitors in patients with DPN control. And then discusses " Jiedu Huoxue,the effect mechanism of Yiqi Bushen " method,and lay the theoretical foundation for the further clinical promotion.Methods:68cases of patients with type2diabetes peripheral neuropathy were randomly divided into two groups,treatment group and control group,each group of34cases. The two groups were2weeks for foundation treatment,(In particular:diet therapy, exercise therapy, insulin hypoglycemic treatment). After2weeks, in the experimental phase,the control group was given in treatment, treatment for8weeks;The treatment group on the basis of mecobalamin plus Ge Jiangtang granule in the treatment of the patients in the treatment group, two times per day take granules, a bag, tor8weeks.To observe the symptoms and signs of patients with DPN before and after treatment for8weeks, at the same time examination before and after treatment. fasting blood glucose(FBG),after breakfast,2h blood glucose(2hPBG)and glycosylatcd hemoglobin; survey nerve conduction velocity (NCV),and the activity of AR monitoring.Rresults:(1) symptoms and signs in treatment group were improved significantly in patients with DPN;(2) treatment group, AR activity was inhibited, significantly lower than the control group (P<005);(3) treatment group, fasting blood glucose, loading2hours blood glucose and glycosylated hemoglobin target is better than control group (P<005);(4)the treatment group electromyography nerve conduction velocity was significantly better than the control group.Conclusion:The "Jiedu Huoxue Yiqi Bushen" in the treatment of type2diabetic peripheral neuropathy,can significantly inhibit the activity of AR in patients with DPN, improve the DPN symptoms and signs, helps to regulate blood sugar,delay the progress of type2diabetic peripheral neuropathy.