Effects Of Resistance Training On Apoptosis And Regeneration In Aged Cardiac Muscle Of Rats

Aim: through the different load of resistance training in aged rats myocardial apoptosisand myocardial regeneration, and the influence of understanding the different load ofresistance training in aged rats myocardial oxidation resistance effects, trying to find out thedifferent load of resistance training in aged rats myocardial apoptosis and myocardialregeneration the influence correlation, and corresponding oxidation resistance of variation, thecrowd of accumulated experiment for future certain theoretical foundation and experimentalreference, but also for the middle-aged and elderly people in the promotion of the effectiveexercise and relatively suitable sport load provide new theoretical basis and practicalguidance.Methods: the study to18months of SD male rats and health for the research object,randomly divided into four groups: aged rats quiet in control group (group C), low load ofresistance training group (L group), medium load of resistance training group (M group), highload of resistance training group (group H). In addition to group C, the other are the10weeksof resistance training.10weekend materials, through the observation group HE dyed in agedrats with myocardial general form, with fluorescence detection each group ofimmunohistochemical method in aged rats with myocardial apoptosis and myocardialregeneration, using the spectrophotometer to measure the aged rats myocardial organizationthe content of MDA and SOD to reflect the aged rats myocardial oxidation resistance changes,and analysis of the difference and relationship between each index.The results:1.10weekend, compared with group C, M group of aged rats HE dyeing myocardialfiber structure is clear, orderly, myocardial cells and the nucleus size well-balanced,interstitial reduced; Group H the myocardial fibers happens disorder, the myocardial fibersarrangement disorder.2.10the weekend, the all experiment group discover myocardial cell regeneration andmyocardial apoptosis phenomenon, compared with group C,L group and group H myocardialapoptosis very to rise significantly (p <0.01), myocardial regeneration to rise significantly (p <0.01); compared with the group C and M group myocardial cell apoptosis verysignificantly (p <0.01), myocardial regeneration to rise significantly (p <0.01). On10theweekend, and aged rats group C myocardial than replacement rate contrast, resistance trainingof L group,M group and group H myocardial are very significant increase of replacement rate(p <0.01).3.10weekend, compared with group C, L group and M group of the aged rats MDAcontent is very significant to decrease (p <0.01), the group H the MDA content increasedsignificantly (p <0.05). Compared with the group C, L group and M group of the aged ratsvery significant SOD activity increased (p <0.01), group H SOD activity decline significantly(p <0.05).Conclusions:1. Through the10weeks of resistance training, training of resistance on the old rats,heart heavy and the greatest power of coefficient, and quiet compared with controls aresignificant rise, this experiment of resistance training model (rats) success.2. Through the immunohistochemical method found myocardial regeneration,myocardial cells that exist regeneration, the experiment of resistance through training,research to prove its heart muscle cells can improve the percentage of myocardialregeneration.3. Through the10weeks of resistance training load, the experimental group ofmyocardial cells in aged rats with total replacement rate are in negative balance state, amongthem with M group of resistance to restrain this kind of negative balance load best effect, andM group anti-oxidant stress aspects of performance is quite comprehensive, increasemyocardial SOD activity and reduce the MDA content, better delay myocardial aging.