| ObjectiveFetal congenital heart disease (CHD), as the most frequent disease of congenitalanomalies in China, is one of the leading causes of infant deaths and disability. Theenvironmental cause of CHD is extremely complex. In the wake of modern industrialdevelopment, environmental pollution and the change of lifestyle, an increasing numberof environmental toxic elements occur in our lives and attract numerous attentions totheir harm during pregnancy. Arsenic, a common toxic heavy metal existing widely in thenature, is suggested embryotoxic and teratogenic in this study as its cumulative actionduring pregnancy. This study explores the relationship between arsenic content inpregnant women’s and the fetal CHD to provide scientific basis for primary prevention ofCHD and the formulation of public health intervention.MethodTo investigate61pairs case-control pregnant women during January,2010toDecember,2011who came from Fujian Provincial Maternity and Child Care Center, weadopted a hospital-based1:1matched case-control study. These pregnant women werematched according to the age and gestational age. All the objects were surveyed usingunification questionnaire and their hairs were collected as samples to test its arseniccontent by using inductively coupled plasma-mass spectrometry (ICP-MS). T test,univariate and multivariate Logistic regression analysis were adopted in this study basedon subgroups devided by the complexity of CHD and the condition of extracardiacanomalies by using The statistical analysis software is SPSS18.0.Result1．The arsenic contents in the hair from CHD group were significantly higher thanthose from control group statistically(P=0.000).2．As the CHD group being devided into simple CHD and complicated CHD,significant difference of hair arsenic contents existed between these two groups and apositive correlation was observed between the specis of cardiac anomalies and the hair arsenic contents(r=0.327，P=0.010).3．As the CHD group being devided by the the condition of extracardiac anomalies,the arsenic contents had not difference between CHD groups with or without extracardiacanomalies(P＞0.050).4．As the CHD group being devided by the complexity of CHD and the conditionof extracardiac anomalies, the arsenic contents between simple CHD groups withoutextracardiac anomalies and complicated CHD group without extracardiac anomalies werestatistically different (P＜0.050).5． By the single-factor Logistic regression, the study showed an increasingtendency of the risk of CHD with the increase of arsenic contents in the hair of pregnantwomen, gradually(OR2=2.474，95%CI：0.617~9.919； OR3=9.315，95%CI：2.203~39.385；OR4=18.770，95%CI：3.833~91.908).6． Cooking(OR=3.950，95%CI：1.029~15.157) and exposure to chemicalpreparation during pregnancy (OR=7.932，95%CI：1.098~57.271) were the key riskfactors contributing to CHD, while drinking dairy products(OR=0.061，95%CI：0.011~0.331) was the protective factor for CHD by multivariate Logistic regressionanalysis. The risk of fetal CHD increased with the increasing hair arsenic contentscalibrated by those influencing factors above(OR2=3.195，95%CI：0.468~21.797；OR3=6.312，95%CI：1.939~42.420；OR4=9.870，95%CI：3.863~74.345).Conclusion1．An increase risk of CHD in pregnant women was observed in the study as theirarsenic content increased, which showed the significant relationship between arseniccontent in pregnant women’s hair and the fetal CHD.2．As the increase of hair arsenic contents, the risk of complicated CHD increased.Extracardiac anomalies did not have any relationship with the hair arsenic contents. Thedevelopment of fetal heart was more sentive than any other organs.3．Cooking and exposure to chemical preparation during pregnancy might be themajor sources of arsenic in pregnant women’s hair. Drinking dairy products frequentlybefore pregnancy might be a protective factor for CHD. |
