Expressions Of Thyroid Hormone And Thyroid Antoantibidy In Breast Cancer Patients And Their Clinical Significance

Objective：To explore the expressions of thyroid hormone(T3, T4, FT3, FT4, TSH),TG(thyroglobulin), thyroid antoantibidy (TPO-Ab, TRAb) in breast cancer patients, andanalyze their relationship with the prognostic factors of breast cancer.Methods：FromJanuary2012to June2012,102breast cancer patients and88benign breast adenomapatients in Breast Surgery of Xinjiang Medical University Cancer Hospital were collected.Preoperative electrochemiluminescence of serum thyroid hormone (T3, T4, FT3, FT4, TGand TSH) levels and TPO-Ab，TRAb expression was performed，and the relationshipbetween them and the clinical and pathological factors of breast cancer was analyzedretrospectively．Chi-square test, Rank sum test, analysis of variance and t test were usedfor statistical analysis．Results：The serum T3level in the breast cancer patients was lowerthan in the patients of benign lesions(P=0.000). TPO-Ab positive rate in the breast cancerpatients was higher than in the patients of benign lesions(P=0.033). T4, FT3, FT4, TSH,TG and TRAb had no statistical difference between the two groups(P>0.050)．Logisticmultifactor analysis: TPO-Ab is the independent risk factors of breast cancer. The decreaseof T3in the breast cancer patients was not related with tumor size,clinical stage, lymphnode metastasis, pathological type, histopathological grade, ER, PR and HER-2, Ki-67expressions (P>0.050). The high expression of TPO-Ab in the breast cancer patients wasnot related with tumor size,clinical stage, lymph node metastasis, pathological type,histopathological grade, ER,PR and HER-2,Ki-67expressions (P>0.050).Conclusions：Thyroid function has certain relation with the progress of breast cancer;determining TPO-Ab may help to evaluate the breast cancer.