Regularity Of Medication For Bi-Disease In Ye Tianshi’s Works" Guide To Clinical Medical Record"

Background:Bi disease,refers to disease appears pain occurs, weight forward, adverse events and other symptoms of limb bones joints,muscles,brings the patients great pain.Rheumatic diseases of modern medicine can Bi as articular synovitis.As people continues to deepen understanding of these diseases,especially in the process of China’s aging population continues to accelerate,rheumatic disease has also been paid extensive attention of scholars. To some extent,Chinese medicine has its own advantage in the prenvention of rheumatic diseases.Modern research on articular aynovitis mostly concentrated in the pathogenesis, diagnosis and treatment,data mining of the drug laws is not enough. Chinese Qing Dynasty is a relatively mature period,Qing Ye Tianshi is one of febrile faction,the creation of "Wei Qi Ying Xue dialectical""triple burner syndrome".Not only that,Ye in diseases such as Bi disease injuri miscellaneous diseases,are also renowed for his contribution.Ye’s life was busy attending services,although the hand writing is small, but most of medical cases recorded by his students,including the mose representative one:"Guide to Clinical case".Objective:Use Traditional Chinese Medicine Inheritance Support System (TTCMISS) for data mining to study the laws of medicine application of Bi-disease in "Guide to Clinical Medical Record", and explore the treatment similarities and dififrences between Bi-disease and other pain syndrome.Method:Collect medical records in CGMR on Bi-disease and other pain syndrome. Standardize the the doze and names of drugs and prescription.Then use TCMISS to analyze the data with frequency analysis, association rules analysis and complex system entropy cluster analysis. Finally, compare the treatment rules of Bi-disease and other pain syndrome to find out similarities and differences.Result:1.In CGMR there are153herbs to treat Bi-disease, and the total frequency were812.It shows that Angelica, Poria, Cinnamon Twig, Atractylodes, wood fangchi are commonly used.Most of these herbs are sweet and warm and mainly constitute tonic prescription, Qufeng desiccant prescription, relieving superficies prescription, promoting blood circulation and removing blood stasis prescription and antipyretic prescription.Treatment method emphasizes invigorating, and includes making Qi and blood abreation, regulating Ying and Wei, and tonifying Yin and Yang.By the correlation analysis, we can get the result that the core treating durgs of Bi-disease are Poria, Atractylodes, Atractylodes, Angelica and astragalus.and18couples of drugsare concluede. Moreover, eight unverified new prescriptions are got based on Entropy clustering analysis.2.Compared with Bi-disease, the commonly used herbs in the treatment of other pain syndrome are Cinnamon Twig, Angelica, Poria. They both share making Qi and blood abreation, eliminating dampness and dredging as the same method.The treatment emphsis is different according to their diverse pathogenesis. Visceral pain emphasis on tonifying spleen and eliminating dampness, and Warming Zhongjiao. Ribs pain emphasis on cooling blood and nourishing Yin, and relaxing the veinto relieve pain.However, comparing other pain sydrome there are many differences on drugs of treating headache, such as clearing head orifices drugs and stillemphasize on purging heat in liver and dispel the wind or invigotating yin and suppress yang.Conclusion:1.It illustrated that are tonic prescription, Qufeng desiccant drugs, relieving drugs, blood circulation drugs and antipyretic are frequently occurring in the Treatment of Bi-disease in CGMR.In addition, The prescription is centered with Poria, Atractylodes, Atractylodes, Angelica and astragalus.Also, We got eight new prescriotions based on entropy cluster analysis.Indeed, we can group these8prescriotion Although, clinical trials are being conducted to gain essential information to verify its effects. Prescriptions focused on driving away stagnated exogenous pathogen.always dispelling cold and removing dampness, removing heat to cool blood, clearing damp-heat.However, Prescriptions focused on tonifying always used to utonify liver and kidney, reinforc qi and nourish blood.2.The commonly used herbs in the treatment of Bi-disease, Visceral pain, Ribs pain are Cinnamon Twig, Angelica, Poria. They both share making Qi and blood abreation, eliminating dampness and dredging as the same method.Visceral pain emphasis on tonifying spleen and eliminating dampness, and Warming Zhongjiao. Ribs pain emphasis on cooling blood and nourishing Yin, and relaxing the veinto relieve pain. However, comparing other pain sydrome there are many differences on drugs of treating headache, such as clearing head orifices drugs and stillemphasize on purging heat in liver and dispel the wind or invigotating yin and suppress yang.3..Only by depends on different pathogenesis can the treatment based on syndrome differentiation. Summarize the specialty of:①It is necessary for those who has got Bi-disease for a long time to tonify deficiency and flow of Qi and blood.②It is benificial for suffers from damp-heat Bi-disease to clear heat-promote diuresis and expelling wind-removing cold.③Ye attaches importance to the inside wind-induced Bi, consequncely, nourish and suppress Yang.④Use light drugs to maintain qi influnce.