The Long-term Efficacy And Multiple-factor Analysis Of Thymus Expanding Resection Treatment For Myasthenia Gravis

Objective To explore the long-term efficacy and related factors of the thymus expandingtreatment for Myasthenia Gravis. Methods We took a retrospective analysis about clinicaldata in62patients who were diagnosed with Myasthenia Gravis and received the thymusexpanding resection+mediastinal fat dissection from January1997to December2011.The postoperative efficacy judgment was in accordance with the American Association ofMyasthenia Gravis: complete remission, partial remission (the above two known aseffective),stability and deterioration. Results The total efficiency was82.3%and the1,3,and5years efficient were85.7%,89.4%,76.9%respectively. The sex composition, age atthe time of operation, postoperative pathological type, whether happened crisis before andafter the surgery, tumor size, age of onset were all unrelated with long-term efficacy（P﹥0.05）. While preoperative course, Osserman typing, whether with other diseases beforeoperation, steroid administration time before operation were related to the long-termefficacy（P﹤0.05）. The thymus expanding resection was the effective means for treatingMyasthenia Gravis;The remission rate and effective rate were gradually improved with theextension of postoperative follow-up time. The efficacy is better in non thymoma thanthymoma with prolonged follow-up time. But there was no statistically difficence betweennon thymoma and thymoma in curative effect.Conclusions The thymus expandingresection is the effective means for treating Myasthenia Gravis; In order to achieve bettercurative effect,the preoperative course, Osserman typing, whether with other diseasesbefore operation, steroid administration time shoud be comprehensively before surgery.