The Effect Of Coronary Angiography On Platelet Activity And Aggregation In Patients With Angina

Objective:Designed to demonstrate the effect of coronary angiography catheterization on platelet activation and aggregation in patients with coronary heart disease.Mothods:All subjects were admitted to the First Hospital Of Zhuzhou between Feb.2012.and Dec.2012. Control group had30patients of whom the CAG is negative.32patients with positive CAG results who were diagnosed with stable angina clinically were recruited as SAP1group.29patients who did not undergo CAG,but were diagnosed with stable angina clinically were recruited as SAP2group:38patients with positive CAG result who were diagnosed with unstable angina clinically were recruited as UAP1group.27patients who did not undergo CAG,but were diagnosed with unstable angina clinically were recruited as UAP2group.Results:①. In the control group, compared with before CAG,the maximum platelet aggregation rate and CD62p positive rate were higher30mins after CAG, and the difference was statistically significant (platelet maximum aggregation rate P<0.05, the positive rate of CD62p P<0.001).②In the SAP1group,compared with before CAG,the maximum platelet aggregation rate and CD62p positive rate were higher30mins after CAG, and the difference was statistically significant (platelet maximum aggregation rate P<0.05, the positive rate of CD62p P<0.001).③. In the SAP2group,compared with before infusion of heparin,the maximum platelet aggregation rate and CD62p positive rate were higher30mins after infusion of heparin, and the difference was statistically significant (platelet maximum aggregation rate P<0.05, the positive rate of CD62p P<0.02).④In the UAP1group,compared with before CAG,the maximum platelet aggregation rate and CD62p positive rate were higher30mins after CAG, and the difference was statistic significant (platelet maximum aggregation rate P<0.050, the positive rate of CD62p P<0.001).⑤.In the UAP2group,compared with before infusion of heparin,the maximum platelet aggregation rate and CD62p positive rate were higher30mins after infusion of heparin, and the difference was statistically significant (platelet maximum aggregation rate P<0.005, the positive rate of CD62p P<0.001).⑥. Before CAG (patients of SAP1) or before infusion of heparin(patients of SAP2) there was no difference in CD62p positive expression rate and the maximum platelet aggregation rate(P>0.5). After CAG (patients of SAP1) or after infusion of heparin(patients of SAP2) there was still no difference in CD62p positive expression rate and the maximum platelet aggregation rate(P>0.5).⑦. Before CAG (patients of UAP1) or before infusion of heparin(patients of UAP2) there was no difference in CD62p positive expression rate and the maximum platelet aggregation rate(P>0.5). After CAG (patients of SAP1) or after infusion of heparin(patients of SAP2) there was still no difference in CD62p positive expression rate and the maximum platelet aggregation rate(P>0.5).Conlusion:The most important factor that affects platelet activation and aggregation of patients with angina is heparin,and there is no significant relationship with other factors.