The Effect Of Qi Ming Granules On Eye And Kidney Damage Of Diabetic Microangiopathy

Objective:The therapeutic effect of diabetic retinopathy treated by QiMing granule is exact, due to diabetic retinopathy and diabetic nephropathy with diabetic microangiopathy,This experiment further studies the effect of QiMing granule on urine albumin excretion rate, discuss the affect of QiMing granule on diabetic microangiopathy.Methods:According to the method of randomized, multi-center, parallel, positive medicine Doxium contrast, analysis included in the standard of94cases of diabetic retinopathy,experimental group given QiMing granule and control group given Doxium,12weeks for a period of treatment,observation2period. visual acuity, fundus (ophthalmoscope, fundus photography, fluorescent angiography), glycosylated hemoglobin, urine albumin excretion rate, etc would be observed.Result:1. The visual acuity improved significantly after12and24weeks’treatment using Qi Ming granule compared with that before treating,(P<0.05). The retinal microaneurysms and hard exudates decreased significantly after24weeks’treatment using Qi Ming granule compared with that before treating (P<0.05). The retinal hemmorage reduced significantly after12and24weeks’treatment using Qi Ming granule compared with that before treating,(P<0.05).2. The urinary albumin excretion rate reduced significantly after12and24weeks’ treatment using Qi Ming granule compared with that before treating,(P<0.05and P<0.01,respectively). There were no significant difference in urinary albumin excretion rate after12and24weeks’treatment using Doxium,(P>0.05). Comparing the results of24weeks’ treatment using Qi Ming granule and Doxium with that before treating respectively, it had significant difference. Comparing the urinary albumin excretion rate in two treatment groups, Qi Ming granule group had5excellent cases (8.19%),50effective cases (81.9%),6invalid cases (9.8%), and Doxium had3excellent cases (9.09%),10effective cases (30.3%),20invalid cases (60.6%), it has significant curative effect (P=0.00)3. The glycosylated hemoglobin decreased significantly after12and24weeks’ treatment using Qi Ming granule compared with that before treating. Compared with that before treating, the glycosylated hemoglobin had no significant difference after12weeks’treatment using Doxium and was significantly different after24weeks’ treatment using Doxium.4. Treated by Qi Ming Granules with24weeks, the triglycerides were significantly improved before the treatment, P<0.05, with statistical significancebefore and after treatment。The triglycerides were improved after being treated with Doxium after12weeks and24weeks, and there was no statistical significance between the differences. Compared the two groups, there was no statistical significance.5. The efficacy of TCMsymptoms and signsof61patients in the Qi Ming Granules group:obvious effects occurred7patients,32patients were effective,22patients were ineffective. theefficacy of TCMsymptoms and signsof33patients in the Doxium group:obvious effects occurred0patients,15patients were effective,18patients were ineffective, between two groups P>0.05,and there was significant difference.6. Urine albumin excretion rate (UAER) and course of DM were positively correlated (P<0.05); and it was not obviously correlated with course of DR and visual sight (P>0.05).it was significantly and positively correlated with fundus hard exudates (P<0.01); and it was obviously correlated with fundus hemorrhages (P<0.05).it was significantly and positively correlated with glycosylated hemoglobin (P<0.01); and it was not obviously correlated with cholesterol and triglycerides (P>0.05)Conclusion: 1. The therapeutic effect of diabetic retinopathy treated by QiMing granule is exact.2. The QiMing granule will lower patients’urinary albumin excretion rate, with the extension of treatment, the efficacy will increase, and the effects is better than the Doxium.3. The QiMing granule willimprove micro vascular complications of diabetes symptoms in TCM, and the effect is better than the Doxium.4. Urinary albumin excretion rate is positively correlated with DM duration, hard exudates, retinal hemorrhage, glycosylated hemoglobin (P<0.05), unrelated tovisual activity, DR duration, microaneurysm.