Curative Observation On The Effect Of The Treatment For Polycystic Ovarian Syndrome Of Kidney-Deficiency And Phlegm-Dampness Type By The Methods Of Kidney-Nourishing And Phlegm-Resolving And Regulating Menstruation Cycles And Its Effect On Insulin Resista

Objective:Through this clinical research, to observe the clinical efficacy of Kidney-Nourishing and Phlegm-Resolving and Regulating Menstruation Cycles Method combined with metformin to cure the Polycystic Ovary Syndrome (PCOS) of Kidney-Deficiency and Phlegm-Dampness.type and observe its Effect on Insulin Resistance(IR).Methods:Collect Kidney-Deficiency and Phlegm-Dampness type of women with PCOS and IR patients whose condition conform the diagnosis standard, and randomize to two groups, the treatment group34cases, and control group26cases, respectively,to Kidney-Nourishing and Phlegm-Resolving and Regulating Menstruation Cycles Method combined with metformin,single metformin,for three menstrual cycles of each therapy(the patients of amenorrhea for three months). Before treatment and after drug withdrawal, contrast the menstruation, TCM syndrome scores, body mass index (BMI), waist-hip ratio (WHR), sign scores of hairy and acne, serum luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH, testosterone (T), prolactin(PRL), estradiol(E2), fasting plasma glucose (FPG), fasting insulin (FINS) level, insulin sensitivity index (ISI), basal body temperature (BBT) during the treatment, menstruation and BBT changes during follow-up time of after three menstrual cycles, and observe the ovulation of the patients who have fertility requirements in the first menstrual cycle after drug withdrawal.Results:The two groups significantly improved the menstrual cycle of fhe patients, the efficacy is no significant difference (P>0.05); the two groups could significantly improve the TCM syndrome, the treatment group’s markedly effective rate is41.18%, and the effective rate is91.18%, compared with the control group (markedly effective rate21.74%, effective rate73.91%), the efficacy is significantly different (P<0.05); also comparing TCM syndrome scores between two groups is significantly different (P<0.05) and the treatment group is better than the control group; in both groups significantly reduced BMI and WHR, the efficacy is significantly different (P<0.01),but the efficacy is no significant difference between two groups after drug withdrawal(P>0.05); the two groups significantly improved the sign of acne, the efficacy is no significant difference (P>0.05), but the improvement of hairy signs is not obvious;in the two groups significantly lower LH, LH/FSH ratio and T levels, after treatment there is no statistical difference for LH and LH/FSH(P>0.05), but the T levels of the treatment group is lower than the control group(P<0.05) and the comparison of FSH, PRL and E2is no significant difference not only before and after treatment but also between the two groups after drug withdrawal(P>0.05); two groups can reduce the FINS and raise the ISI levels, after treatment between the two groups there are significant differences(P<0.01), but FPG is no statistical difference(P>0.05); the treatment group’s BBT duplex rates is62.69%, compared with the control group(39.22%) the efficacy is significantly different (P<0.05); during follow-up time of after three menstrual cycles, the patient’s menstruation is more shorten than before the treatment and there is no significant difference between the two groups(P>0.05), and the treatment group’s BBT duplex rates is73.17%, compared with the control group(54.24%) the efficacy is significantly different (P<0.05); B-mode ultrasound monitoring ovulation discovered the treatment group’s ovulation rates is75%and the control group’s ovulation rates is58.33%and they have no significant change (P>0.05) in the first menstrual cycle after treatment; generally speaking, the treatment group’s markedly effective rate is35.29%, and the effective rate is91.18%, compared with the control group (markedly effective rate17.39%, effective rate73.91%), the efficacy is significantly different (P<0.05), and the treatment group is better than the control group.Conclusion:Kidney-Nourishing and Phlegm-Resolving and Regulating Menstruation Cycles Method combined with metformin to cure the patients with PCOS and IR, could improve the patients’ menstrual cycle, TCM syndrome (the treatment group is better than the control group), clicinal signs, hormone disorders of women, insulin resistance status and recovery BBT biphasic, and during the follow-up time after the treatment the patients’ ovulation rates and BBT duplex rates increace and menstrual cycle compared with before treatment reduce. For short-term the prognosis is good, and there are no significant adverse reactions, and the patients have high compliance.