Studies On Efficient And Green Synthesis Of Amide And Phosphonate Derivatives By Ionic Liquid [Bmim]OH Catalysis

In recent years, the applications of ionic liquids as green and efficient catalysts have obtained considerable development. This thesis reported two efficacious synthesis reactions catalyzed by alkaline ionic liquids of [Bmim]OH:(1) the synthesis of acyl amide derivants on the catalysis of ionic liquid [Bmim]OH;(2) theα-hydroxylation of phosphonate compounds on the catalysis of ionic liquid[Bmim]OH.(1) The constructions of acyl amide bond have been the research priority and focus in the modern organic chemistry, since the important applications of acyl amides in many fields such as polymer synthesis, medicinal chemistry and biochemistry. The synthesis processes of their conventional synthesis method often need to use the catalysts of peroxide, carboxylic acid activator, organic or inorganic base, transition metals, etc. Even though new methods for synthesis of acyl amide compounds from azide have rapidly been reporting and developing in recent years,there are still some deficiencies. These synthesis processes often need to use the catalysts of guide groups or transition metal which would harm to the environment. In this paper, a new synthesis method of acyl amides was described base on the catalysis of ionic liquid [Bmim]OH. The acyl amides synthesis was realized in the reaction of azide and aldehyde amide with [Bmim]OH as catalyst and non-volatile reaction medium in mild condition. The catalyst can be recycled, which is a resource conservation to good purpose. What’s more, only nitrogen gas, an environmental-friendly by-product, was produced. This method points out a way of efficient and green synthesis of amide compounds.(2) α-hydroxy phosphonate derivatives play an important role in the biomedical field. α- hydroxy phosphonate products more active and more likely to be further oxidized than the phosphate reactant. It is a challenging of phosphonate direct hydroxylation. Method for the synthesis of α-hydroxy phosphonates derivatives almost use organic or inorganic acid, alkali, transition metals as catalyst, which does not meet the concept of green development. In this thesis, with using oxygen and from phosphonate compound, α-hydroxy phosphonate derivatives were synthesized by ionic liquid [Bmim]OH as catalyst and solvent at room temperature. Oxygen molecular as the oxidant and oxygen atom source, which is correspond the requirements of green chemistry. This reactions would enrich the synthesis method ofα-hydroxy phosphonate derivatives, which would facilitat more applications in biomedicine and biopesticide.