In The Peripheral Blood Of Adults With Epilepsy GADA、ANA Level Change And Significance

Objective: to observe the peripheral blood of adults with epilepsy of glutamic aciddecarboxylase antibody (GADA) and antinuclear antibodies (ANA) level，the analysisof two kinds of autoantibodies and the correlation of adult epilepsy and to explore theeffect of immune dysfunction in adult epilepsy and the pathophysiology of possible，provide a new approach to the prevention and treatment of epilepsy.Methods:30cases of epilepsy patients as case group，30cases of healthy check-upshall be considered as normal control group，in accordance with into a set of criteria andexclusion criteria. Adopt the method of comparison research，case group preliminarydivided into implicit source based on the cause epilepsy group and symptomaticepilepsy group. Records of the patient’s clinical seizure type，laboratory examination，imaging examination，electroencephalogram and general situation. Collected on anempty stomach peripheral blood using enzyme-linked immunosorbent method (enzymelinked immunosorbent assay，ELISA) testing GADAand ANA. The results using SPSS20.0statistical software analysis，for each variable uses the normality test，quantitativedata comparison between the two groups，accord with normal distribution using t test;Do not conform to the normal distribution，the Kruskal-Wallis detection method.Sample rate compared with chi-square test，when n <40or T <1used to probabilitymethod. for quantitative data correlation analysis between the two groups，the data donot accord with normal distribution， the Spearman rank correlation analysis.Comparative analysis of the application of two sample mean t test，paired t test andanalysis of variance，correlation analysis using the linear correlation analysis method.for classification variables using chi-square，differences between the complete set ofinspection. The results for the test to α=0.05level as the inspection level，inspection isthe level of significance of bilateral P <0.05. Results:1、hidden source sex，positive predictive value of serum GADA symptomaticepilepsy group (17.6%，10%) were significantly increased compared with normalcontrol group (P=0.017<0.05，P=0.020<0.05)，a hidden source sex epilepsy groupof GADA positive rate increased significantly in the symptomatic epilepsy group (P=0.024<0.05). Symptomatic epilepsy group GADA serum positive rate and course ofsignificant positive correlation (r=0.398，P=0.04<0.05). Hidden source sex epilepsygroup serum GADA positive rate and abnormal fasting glucose was significantlypositive correlation (r=0.549，P=0.003<0.01).2、hidden source sex，symptomatic epilepsy group serumANApositive rate (35.3%，9.1%) were significantly increased compared with normal control group (P=0.016<0.05，P=0.032<0.05)，a hidden source sex the ANA positive rate of epilepsy groupincreased significantly in the symptomatic epilepsy group (χ2=0.151，P=0.030<0.05)，two groups of theANApositive rate and course of significant positive correlation(r=0.109，P=0.023<0.05；r=0.071，P=0.018<0.05)，while no significantcorrelation with abnormal blood glucose.3、GADAand has significant correlation between the ANA(χ2=18.987，P <0.01).Conclusion:1、There is a humoral immune abnormalities of adult epilepsy patients.2、Hidden sources of epilepsy patients abnormal immune is more than thesymptomatic epilepsy grou.3、There may has a positive significant positive correlation that adult epilepsypatients with GADAand ANA.