The LETM1Protein Overexpression And Its Clinicopathological Significance In Uterine Cervical Cancers

Purpose To investigate the Clinicopathological significance of LETM1protein overexpression on prognostic evaluation of cervical cancer.Materials and Methods Total164cases of cervical lesion archive wax block, including94cases of cervical squamous carcinoma tissue,12cases of cervical adenocarcinoma tissue,15cases of CIN I tissue,22cases of CIN Ⅱ-Ⅲ tissue and21cases of normal cervical epithelium tissue,-were selected in this study. Immunofluorescence method was used to assess the subcellular localization of the LETM lprotein in the HeLa cell, Immunohistochemistry for LETM1protein was done in all above cases, and prognostic significance.was alos analyzed.Results The results of immunofluorescence and immunohistochemistry show that the LETM1protein was located in cytoplasm in HeLa cells. The positive rates of LETM1protein were significantly higher in CINI (20%,3/15), CIN H-Ⅲ (27.3%,6/22), cervical squamous cell carcinoma (60.6%,57/94) and cervical adenocarcinoma (75.0%,9/12) compared with the normal cervical epithelia (9.5%,2/21)(p<0.05). Additionally, the positive rates of LETM1protein in poorly differentiated cervical cancer were significantly higher than that in well-differentiated cervical cancer, and the positive rates of LETM1protein in terminal cervical cancer were also significantly higher than that in early cervical cancer (P<0.05). The LETM1protein expression was not statistically correlated with the age of patients、tumor size and metastasis of the cervical carcinoma.Conclusions LETM1overexpression might be a new biomarker of cervical cancer and evaluate the prognosis of cervical cancer.