Correlation Analysis Of Hs-CRP And TNf-α In Gingival Crevicular Fluid And Type Ⅱ Diabetes With Chronic Periodontitis

Objective:To research the correlation of the level of high-sensitivity C-reactive protein (hs-CRP), and Tumor necrosis factor-a(TNF-a) in the gingival crevicular fluid with Type II diabetes and Chronic periodontitis and their function in the interaction of these the two diseases;Methods:The research chose120patients,30in a group. Which respectively have Type II diabetes, Chronic periodontitis and Type II diabetes with periodontitis in three experimental groups and30healthy as control group. Extraction of the gingival crevicular fluid of subjects with the method of moisture absorption paper, and level detection of hs-CRP with the immunfluorescence detection kit and level detection of TNF-a by EPO ELISA kit were done. Age is compared by single factor of variance, gender composition by χ2inspection, the comparison of TNF-a and hs-CRP level used2×2factorial analysis of variance, the data use SPSS16.0software for statistical analysis; p<0.05as the inspection standard.Results:The levels of hs-CRP and TNF-a in experimental groups are higher than the healthy controls, and the differences show statistically significance (p<0.05). The levels of hs-CRP and TNF-a in Type II diabetes group are higher than the Chronic periodontitis and the difference shows statistically significance (p<0.05). The level of hs-CRP and TNF-a in the T2DM-CP group have little interaction (p>0.05). The difference show no statistically significance.Conclusion:The levels of hs-CRP and TNF-a in Gingival crevicular fluid have relationship with both Chronic periodontitis and Type II diabetes, the two diseases can both increase the level of hs-CRP and TNF-a in Gingival crevicular fluid, and there is a more obvious effect in Type II diabetes.