The Compound Maodongqing Enema Combined Mesalazine Enteric-Coated Tablets Treatment Of UC

ObjectiveObserve the effects of compound mesalazine enteric-coated tablets combined Maodongqing retention enema to treatment of large intestine damp-heat moderate distal ulcerative colitis and its clinical efficacy after treatment CRP, ESR indicators.MethodsClinical study selected in accordance with the diagnostic criteria, inclusion criteria, exclusion criteria66cases of patients with ulcerative colitis damp-heat in the large intestine meet the standards for the study were randomly divided into two groups, Treatment groups:33cases of compound Maodongqing enema (100ml) joint mesalazine enteric-coated tablets (1g,3times/day), control group:33cases of mesalazine enteric-coated tablets (1g,3times/day), the same basic treatment groups (such as general rest, nutritious diet, reasonable exercise), the control group, enteric-coated tablets for oral mesalazine treatment on the basis of the treatment, the treatment group and the control group except Maodongqing enema treatment with compound, course of eight weeks, syndromes observed points, colonoscopy and CRP, ESR changes before and after treatment in both groups after treatment to evaluate the joint compound Maodongqing mesalazine enema enteric-coated tablets for mild to moderate distal ulcerative colitis therapy and adverse reactions. Establish a database for statistical analysis using SPSS18.0statistical methods including t test, Wilcoxon rank sum test, X2test, Mann-Whitney U test and so on.ResultClinical studies have shown the total effect of the two groups TCM symptoms, symptom scores, CRP, ESR, colonoscopy efficacy varying degrees of improvement. Two syndromes overall efficacy compared using Mann-Whitney U test, known P <0.05, the difference was statistically significant, the test results showed that the treatment group and the control group TCM symptoms and the total effective rate96.97%and90.90%in treatment group, treatment group than in the control group; Change before and after treatment ESR and CRP levels, using wilcoxon rank sum test, within the group:Compared with before treatment,*P<0.01; between the two groups:compared with the control group, ΔP<0.05, the results showed CRP, ESR before and after comparison of each group were significant group differences (P<0.01), between the two groups after treatment, the degree of improvement in treatment group than the control group. Effects were compared colonoscopy, using Mann-Whitney U test, known P<0.05, the difference was statistically significant, the test results indicate the two groups and the total effective rate was96.97%and78.79%, the treatment group than the control group.ConelusionCompound hairy Holly enema retention enema combined beauty salad oxazine enteric-coated metformin hydrochloride treatment of colon syndrome light, moderate distal ulcerative colitis curative effect is good, can effectively improve patients with symptoms of TCM and colonoscopy, and can reduce the patients with CRP, ESR levels.