The Therapeutic Observation On Depression-Related Insomnia Of Tian-Meng Oral Combined With Mirtazapine Pill

Objective: Depression is associated with intractable insomnia neurology clinic of a class of common psychosomatic diseases, incidence 30-40%. Depression and other mood disorders and make life a serious decline in the quality of life of patients. Study found that patients with depression associated with intractable insomnia is a genetic, environmental and social factors result of many factors; neurotransmitter, neuroendocrine disorders, neurological immune response may be associated with psychosocial pathogenesis, specifically pathogenesis remains unclear. In a series of physiological disorders and depression symptoms as the main clinical manifestations, their families and doctors are unlikely to cause clinical attention, so a high incidence of depression, and the diagnosis rate, poor treatment. If this is the case of depression, if not treated effectively, not only affect the patient’s daily life, but also to society and the family brought a heavy burden, and increase the risk associated with other diseases, in a way. Antidepressants in the treatment of depression insomnia, although a positive effect, but more adverse reactions and withdrawal rebound phenomenon, so that the patient medication adherence decreased. Currently, the disease, TCM drugs and clinical and experimental studies on depression insomnia in the field of medicine has made significant development, showing some potential medicine to treat depression have insomnia. But because there are individual differences in traditional Chinese medicine, the slow onset of issues such as the combination therapy of depression insomnia has attracted wide attention. Depression, insomnia treatment with Western medicine can play their respective advantages, a combination that minimizes adverse reactions and increase the long-term effect, and the patient is easy to accept. This study was designed to investigate the effects of combined oral Sweet Sleeper mirtazapine tablets in clinical efficacy with depression insomnia, and explore new ideas, new ways to treat depression provided Integrative Medicine has opened up a new way of treating disease.Methods : Will meet the diagnostic criteria for depression, 60 patients were randomly divided into two groups: the study group and the control group. Study group of 31 patients, including 13 cases in males and 18 females; control group of 30 patients, including 12 males and 17 females; study group with mirtazapine tablets joint Sweet Sleeper oral medication method: 30 mg per meal once. Sweet Dreams oral medication: once g, three times a day, after meals, taking a total of eight weeks. The control group using only mirtazapine tablets in the treatment, medication method with the study group.(Before the group can not take any other antidepressants, and blood concentration of 7 days cleaning). Hamilton Anxiety Depression Scale(HAMD) were to evaluate the degree of depression was measured according to the validity of HAMD reduction rate of change; to evaluate the efficacy of sleep with the Pittsburgh Sleep Quality Index scale(PSQI), in order to reduce the Pittsburgh Sleep Quality Index fraction calculation subjective sleep efficiency. Before and after treatment to check the patient’s blood, urine, liver function, kidney function and ECG were observed and adverse reactions recorded.Results:1 Tian-Meng Oral and mirtazapine for depression and insomnia symptom s improved significantly in patients, compared with before treatment, both groups have a more obvious HAMD scores decreased, and the treatment group decreased more significantly(P <0.01).2 The treatment group and the control group at 4 weeks of treatment, and treatment of pre-HAMD scores were statistically significant comparison(P <0.05); after 8 weeks of treatment, the reduction rate is calculated by HAMD efficient treatment group was 83.52 % in the control group was 68.37% in the treatment group than the control group; the treatment group than the control group; in terms of improving the quality of sleep, after eight weeks of treatment, both groups PSQI score was significantly lower, reducing the treatment group was significantly better(P <0.01); have PSQI reduced rate to calculate the treatment and control groups after 8 weeks of efficiency, the two rates were 80.58% and 70.28%, respectively, in the treatment group than the control group. Before and after treatment, both groups urinalysis, liver and kidney function, electrocardiogram showed no abnormalities. In the application of adverse reactions, clinical observations show a low incidence of adverse hair should be treated.3 Sweet sleeper combined oral mirtazapine in the treatment of depression with insomnia safe range, less incidence of adverse reactions, the two groups was statistically significant difference(P <0.01).Conclusion:1 Tian-Meng Oral combined with mirtazapine can significantly improve the quality of sleep in patients with mood disorders and reduce a series of somatic symptoms and improve quality of life of patients and reduce the adverse effects of mirtazapine antidepressant.2 Sweet Sleeper combined oral mirtazapine tablets in the treatment of depression, insomnia, improve depression symptoms and improve the quality of sleep in patients with respect better than single mirtazapine group, and rapid onset of adverse reactions.