The Epidemiology Survey Of The Prevalence Of Periodontitis In Viral Hepatitis Patients

Objective:Various studies conducted abroad have demonstrated that periodontitis can affect non-alcoholic fatty liver disease, liver carcinoma and liver transplantation, assuming that periodontitis may exacerbate the progress of these conditions, but all these studies have neglected the relationship between viral hepatitis along with its related cirrhosis and periodontitis. This study was aimed at discovering the relationship between viral hepatitis along with its related cirrhosis and periodontitis.Materials and methods:This study was conducted in the liver disease treatment center of PLA of The International Bethune peace Hospital. A total number of 221 subjects including patients and their family members were enrolled in this survey. The survey was conducted in a cross-sectional manner. The survey was consisted of two parts, namely questionnaire survey and oral clinical examination. The questionnaire was filled by the interviewees at site and the oral examination was performed right after by authorized dentist right after. The results of two dentists’examination were standardized, and the consistence test showed high consistency (kappa=0.95). In order to minimize the interference of drug administration, we only selected the initial data of the first medical record. The patients with viral hepatitis were divided into two groups, namely non-cirrhosis goup and cirrhosis group. The liver condition of cirrhosis group was evaluated using improved Child-pugh score system. The improved Child-pugh score system is a widely applied clinical measurement used to evaluate the reserved liver function of cirrhosis patients. After a certain algorithm, all scores were added with 5 being the lowest and 15 being the highest. The data was analyzed using SPSS 19 software. Using two-sample t test to analyze the difference of attachment loss between viral hepatitis group and healthy, then dived the subject into subsets according to their age and using same statistical method with the subsets. Using linear correlation to analyze the relationship between attachment loss and Child-Pugh score. Using backward stepwise non-conditional logistic regression to evaluate different variables’contribution to the occurrence of periodontitis, such variables include age, sex, education, smoke, drink and Child-Pugh score.Results:A total number of 230 people participated in this survey,100 patients’family members and 121 patients entered the final analysis. The result showed that the different incidence rate of mild-to-severe periodontitis between healthy control and patients is of statistical significance, P<0.01; The different incidence rate of mild-to-severe periodontitis between smoking and non-smoking subjects in healthy control is of statistical significance, P<0.01, the different incidence rate of mild-to-severe periodontitis between hepatitis patients and healthy control in non-smoking group is also of statistical significance, P=0.014; The different incidence rate of mild-to-severe periodontitis between drinking and non-drinking subjects in healthy control is of statistical significance, P=0.015, the different incidence rates of mild-to-severe periodontitis between hepatitis patients and healthy control in both drinking and non-drinking group are of statistical significance, P=0.038 and P=0.015,resPectively; The different incidence rates of mild-to-severe periodontitis between well educated and poor educated in both hepatitis and healthy control group are of statistical significance, P<0.01, the different incidence rates of mild-to-severe periodontitis between hepatitis patients and healthy control in poor educated group is of statistical significance, P<0.01; only the different incidence rates of mild-to-severe periodontitis between hepatitis Patients and healthy control in female group is of statistical significance, P<0.01.Two-samPle t test shows that the average attachment loss in patients group is greater than healthy group, the difference is statistically significant (P<0.01). The statistical difference remains (P<0.05) after dividing the subjects into subgroups due to their ages except for subgroup aged 50-59.In the logistic regression analysis, we found that, in the healthy group, age and drinking entered the final equation meaning they are possible risk factors for periodontitis. In contrast, we found that only Child-Pugh score enter the equation in liver cirrhosis group meaning it is the risk factors for middle-severe degree of periodontitis.Conclusion:The Periodontal attachment loss in viral hepatitis Patients is much severer than healthy group. The Periodontal attachment loss in viral hepatitis induced liver cirrhosis is severer than non-cirrhosis hepatitis patients. After dividing the subjects into subgroups according to their ages, only the difference of attachment loss between patient group and healthy group in 50-59 years old group is not of statistical significance. There is no statistical significance of the difference of attachment loss between hepatitis virus type B patients and hepatitis type C patients. The periodontal attachment loss is significantly correlated with Child-pugh score (P<0.01). Viral hepatitis is a risk factor for periodontitis.