| Objective:To analyze the situation of hepatitis B virus (HBV) and HCV infections of primary liver cancer (PLC) inpatients, as well as the role of mono-infection or co-infection of HBV and HCV in the occurrence of PLC in Guangxi in the recent 10 years. And further to explore the composition of HBV and HCV infection in PLC inpatients, along with the causes of high incidence of PLC in Guangxi, so as to provide the basis for effective clinical intervention of PLC.Methods:1.74 serum samples from PLC were collected from serum specimen bank which was established by collecting serum samples from high incidence area of PLC in Guangxi.148 serum samples with positive HBsAg collected from the same specimen bank were screened to the high-risk group. Meanwhile,148 serum samples with negative HBsAg were selected to the control group. The anti-HCV in serum was quantitatively detected with enzyme-linked immune sorbent assay (ELISA). The positive rates of each group were calculated and then were analyzed using chi square test.2. A total of 6201 PLC inpatients in the affiliated tumor hospital of Guangxi medical university during 2004 to 2013 were enrolled. The HBsAg and anti-HCV in serum were detected using time resolved fluoroimmunoassay and chemiluminescence immunoassay respectively. HBV and HCV infection situation were analyzed in terms of gender, age as well as area.Results:1. The HBV, HCV infection of subject investigated from high incidence area of PLC in Guangxi:HBsAg positive rates of the PLC group, high-risk group and control group were 100%,100% and 0% respectively. Results of serum anti-HCV in the three groups were negative.2. The HBV, HCV infection of PLC inpatients:2.1 Based on the results of all PLC inpatients, HBsAg positive rate was 84.76%(5256/6201), anti-HCV positive rate was 1.42%(88/6201), and the positive rate of HBV and HCV co-infection was 0.68%(42/6201). The HBsAg positive rate of male PLC inpatients was significantly higher than that of female.2.2 PLC inpatients were mainly concentrated in 30-69 years age group (90.05%), which occurred most frequently in 40-49 years age group (28.70%) and followed by 50-59 years age group (27.90%). Among PLC inpatients, positive HBsAg cases were also mainly distributed in 30-69 years age group (91.59%), while positive anti-HCV cases were mainly distributed in 40-79 years age group (95.45%).2.3 The HBsAg positive rate of PLC showed an increasing trend with age which reached the peak in 30-39 years age group (94.95%), and then decreased with age. The anti-HCV positive rate showed the similar trend from 30-39 years age group, whereas reached peak in 70-79 years group (3.74%), and then decreased significantly.2.4 During 2004 to 2013, the majority of PLC inpatients were from Nanning city (28.43%), Guigang city (12.50%), Chongzuo city (11.05%) and Yulin city (9.56%), which accounted for 61.54% in total. The constituent ratios of PLC inpatients with positive HBsAg were also at a high level concerning the above areas. The constituent ratios of positive anti-HCV inpatients were relatively high in Nanning city (28.41%), Guigang city (15.91%), Yulin city (9.09%), Guilin city (7.96%) and Hechi city (7.96%).2.5 The PLC inpatients in Fangchenggang (90.84%), Liuzhou (89.26%), Hezhou (89.19%), Wuzhou (87.32%)showed a significantly elevation of HBsAg positive rate, compared with that in Chongzuo (83.07%), Nanning (82.98%), Hechi (79.77%). The anti-HCV positive rates of PLC inpatients were relatively higher in the following areas:Guilin(4.86%), Wuzhou (4.23%), Fangchenggang (3.05%) and Liuzhou (2.69%).2.6 The prevalence rate of liver disease (including viral hepatitis, liver cirrhosis and liver cancer) for the first-degree relatives of PLC inpatients was 15.90%, which was significantly higher than that for the secondary relatives (0.67%).Conclusion:The occurrence of PLC was closely associated with HBV infection in Guangxi province. Nevertheless further studies are needed to examine the relationship between PLC and HCV infection. Although HBV infection was still the primary etiology of high PLC incidence in Guangxi province, HCV infection also should not be ignored. Therefore, preventing HBV and HCV infection effectively is an important measure for PLC prevention and treatment. |
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