The Influence Of Flavored Huanglian Jiedu Decoction On CORT And NT Content In Serum On Gastric Ulcer Toxic Heat Syndrome Model Rats And Clinical Syndrome Curative Effect Observation

ObjectiveThis topic aims to experimentally study to observe the effect of Flavored Huanglian Jiedu Decoction on gastric ulcer toxic heat syndrome serum levels of CORT and NT,and through clinical syndrome curative effect observation to explore the mechanism of action of Flavored Huanglian Jiedu Decoction on gastric ulcer and its clinical syndrome curative effect, which will provide a scientific basis for their treatment of gastric ulcers toxic heat syndrome.Methods1.Animal experimentation90healthy SD rats were randomly divided into blank group, model group, Flavored Huanglian Jiedu Decoction high dose group, middle dose group, low dose group and omeprazole group, each group of15only. To each other than the blank group rats model, advance pepper spray with ethanol mixed suspension rat gastric lavage induced toxic heat model, the gastric mucosa acetate injection with one hundred percent of the ice making rat gastric ulcer model.Building after6days began to fill the stomach, the blank group and model group to the amount of normal saline lavage, the rest of the group to the corresponding drug lavage, once a day, continuous lavage fourteen days. Executed in rats after the completion of the treatment, took the femoral arterial blood to detect the content of CORT and NT in serum, and watched the rat gastric mucosa tissue pathological changes. The data line by SPSS17.0statistical processing.2. Clinical syndrome curative effect observationChose30cases of clinic patients according with standard, to Flavored Huanglian Jiedu Decoction clinical disease to add and subtract, oral treatment for3weeks. Drug delivery was completed according to the contrast before and after treatment in patients with symptoms of quantitative integral to evaluate its curative effect. Results1. The impact on levels of CORT and NT:Compared with the model group, Flavored Huanglian Jiedu Decoction each dose group and omeprazole group could reduce CORT levels, increase NT content (P<0.05or P<0.01), and Flavored Huanglian Jiedu Decoction high dose group was better than that of omeprazole group.2. The impact on pathology:Compared with model group, treatment group could reduce ulcer index, ulcer grade, fibrosis score and inflammatory cells infiltrationo in different degrees, and could improve the ulcer granulation tissue score (P<0.05or P<0.01), of which the Huanglian Jiedu Decoction high dose group of the most obvious.3. Clinical syndrome curative effect observation:After treatment, the patient symptom scores decreased significantly (P<0.05), the clinical total effective rate was93.33%, no drug adverse events during treatment.Conclusion1. The experimental conclusion:Flavored Huanglian Jiedu Decoction can effectively promote the healing of stomach poison heat ulcer of rats and its mechanism of action may by reducing mucosal damage factor of CORT levels and improve the level of mucosal protection factor of NT, thereby inhibiting gastric acid secretion and gastric bowel movement, protecting the gastrointestinal mucosa to promote ulcer healing.2. The clinical conclusion:Flavored Huanglian Jiedu Decoction can effectively improve the clinical symptoms of patients with gastric ulcer of toxic heat, syndrome curative effect affirmation, and found no adverse drug events during treatment, worth clinical promotion.