Mechanism Research Of Benefiting Qi For Activating Blood Forluma On Coronary Heart Disease Of Heart-qi Deficiency

Objective: To investigate the effects of Benefiting Qi for Activating Blood Circulation Formula on Coronary Heart Disease(CHD), we summarized and concluded CHD Heart-qi deficiency theories and explored potential drug targets and mechanism with changes of catecholamine contents, such as epinephrine(E), norepinephrine(NE) and cyclic adenosine monophosphate(c AMP).Methods: Rats model of CHD of heart-qi deficiency were established by ligation of left anterior descending coronary artery combined with L-NNA intraperitoneal injection. We carried out dynamic intervention for both groups that the experimental group was fed with low, medium or high-concentrated Benefiting Qi for Activating Blood Circulation Formula decoction while the control group was given Dilitiazem Hydrochloride. Then we observed pathological changes of myocardium and analyzed catecholamine contents changes, including E, NE and c AMP of rats.Results: The rats model established generally conformed to clinical CHD patients manifestations and changes of plasma parameters detected were consistent with those of the clinical experiments. After the intervention of Benefiting Qi for Activating Blood Circulation Formula, the physical state of heart-qi deficiency rats model got significantly improved that it decreased levels of catecholamine contents and c AMP, repaired damaged myocardium and improved heart functions.Conclusion: It is an effective way to establish rats model through ligation of left anterior descending coronary artery combined with L-NNA intraperitoneal injection. And Benefiting Qi for Activating Blood Circulation Formula shows favorable effects on rats model of CHD heart-qi deficiency, which regulating catecholamine contents(E, NE and c AMP) maybe one of important mechanism, with the GS-AC-c AMP-PKA signal channel, so that the myocardium and heart functions are improved.