Clinical Studies In Patients With Shen Mai Injection Combined With CIK Of Advanced Non-small Cell Lung Cancer

Objective: Through clinical observation and experiment,to generate the differences in efficacy of non-small cell lung cancer patients who is Qiyinliangxu after chemotherapy, Injection Shen Mai combined with cytokine-induced killer(CIK)cells and separate sequential CIK treatment.Method: 1.30 non-small cell lung cancer patients who is Qiyinliangxu after chemotherapy will be selected, during the period of December 2012 to January 2015.TNM stage Ⅳ, chemotherapy cycle all over and do not receive targeted treatment, KPS score more than 50 points, showed symptoms Qiyinliangxu according to Chinese clinical medicine.2. Randomly divided into control group and observation group, 15 cases in the Control group, single treatment with CIK; 14 cases of the Treatment group, Shen Mai Injection Combined with CIK treatment. The CIK treatment will be will be applied after chemotherapy cycles were all over one week, Every time per person will be intravenous transfusion CIK cell suspension 200 ml, continuous infused of two days for a course, each course CIK cell suspension of 400 m L, the total number of cells is greater than 4 × 109,research for 5 courses. Every day the dosage of Shen Mai Injection is 60 ml per person in Observation group, combined with 0.9% sodium chloride solution, continuous infused of 14 days for a course,research for 4 courses.Fill in Tables before and after treatment, comparative analysis of the before and after integration. Peripheral blood CD3~+,CD4~+, NK cells and the ratio of the level of CD4~+/CD8~+cell were detected before and after treatment.Results: 1.After statistical analysis, the efficiency of treatment group was 64.3%(P <0.05), there was significant; the control group improved symptom scores of the effective rate of 33.3%(P <0.05), there was significant. The treatment group and the control group could reduce the symptoms of advanced non-small cell lung cancer patients integration. But the treatment group was significantly more than the control group of symptoms, and there is more efficient. Group t tests showed, P <0.05, two treatments in patients with TCM symptoms integral difference was statistically significant improvement in the treatment group improved symptom scores higher.2.Degree of improvement before and after the treatment group was significantly higher than the control group(P<0.05), statistically significant. A group t test showed(P<0.05), two treatment methods for patients QOL score difference was statistically significant, improvement in the treatment group was higher on QOL.3.Before and after treatment of peripheral blood lymphocyte phenotype treatment group compared 14 patients peripheral blood CD3~+, CD4~+, NK cell ratio and CD4~+/CD8~+ ratio before treatment were increased(P<0.05). The control group and the treatment group difference was not statistically significant(P>0.05).4. Two groups did not occur after treatment adverse reactions. Group of white blood cells before and after treatment, hemoglobin, platelets, ALT, creatinine, BUN, security analysis and comparison no significant difference(P>0.05).Conclusion: non-small cell lung cancer after chemotherapy with sequential Shen Mai injection combined with sequential CIK can improve the symptoms of patients with lung cancer and improve the treatment of life; SM group effect is more pronounced. The clinical application of the two groups were not found adverse reactions.