Influence Of Low Birth Weight On The Increased Risk Of Post-partum Hypertension

Objective To compare the prevalence of hypertension between low birth weight infant(LBWI)women and non-LBWI women.Methods A retrospective cohort study was applied. In our study, 3 172 pregnant women who had gave births during October 1976 to December 2008 in Kailuan medical group and underwent physical check-up between 2010 and 2011 at the Kailuan employees health insurance center without history of hypertension before pregnant,secondary hypertension, abortion or miscarriage, missing birth weight and missing research data were included.All workers were observed the prevalence of hypertension.These pregnant women were divided into LBWI group and non-LBWI group by the history of LBWI. Prevalence of hypertension was obtained during the follow-up program. Multiple logistic regression analysis was used to assess the relative risk of hypertension.Results 1 A total number of 3 172 women,with age of 24~72 and an average age of 42.3 years old were divided into LBWI group(n=147)and non-LBWI group(n=3 025),and the average birth weights of their infants were 2.31 kg and 3.39 kg,respectively. LBWI was 4.6% of the total number of deliveries. 2 The number of hypertension in the LBWI group was 35 and in the non-LBWI group was 511.The prevalence of hypertension from the follow-up program was significantly higher in LBWI group than that in the non-LBWI group(23.8% vs. 16.9%,P<0.05). 3 Multiple logistic regression analysis show that the risk of hypertension in LBWI group was 1.54(95%CI:1.04~2.27)fold higher than that in the non-LBWI group. After adjustment for birth age and postnatal SBP on this basis, the risk of hypertension in LBWI group was 1.66(95%CI:1.09~2.54)fold higher than that in the non-LBWI group. After adjustment for other traditional risk factors such as birth age,postnatal SBP, BMI, FBG, HDL-C, LDL-C, TC, TG, hs CRP on these basis,the risk of hypertension in LBWI group was 1.60(95%CI:1.02-2.53)fold higher than that in the non-LBWI group.Conclusion Prevalence of hypertension in women with LBWI was higher than that in those women without LBWI.History of LBWI seemed to have had an increased risk to develop hypertension.Table4; Reference 123...