Efficacy Observation On Maxing Shigan Decoction Add Zhisou Powder On The Treatment Of Acute Bronchitis (Syndrome Of Wind-heat Invading Lung)

Objective: To evaluate the clinical curative effect of Maxing Shigan Decoction and Zhisou San on acute bronchitis (Syndrome of Wind-heat Invading Lung).by observing the attack frequency of cough, cough symptoms integral, bronchial symptoms severity score (BSS) score, the curative effect of TCM syndrome integral before and after treatment.Methods:1. The clinical data The observation was divided into experimental group and control group which all conform to the diagnostic criteria of acute bronchitis. The random parallel contrast methodis adopted to observe the 60 patients,30 cases in each group. The baseline data were comparable between two groups.2. Drug usage experimental group:Maxing Shigan decoction and Zhisou powder, oral 100ml/bag,3 times a day, once a bag; Control group:Tai Chi in the syrup. 100ml/bottle, oral,20ml/time,3 times a day. The course of treatment was 7 days. To observe the changes of symptoms、 signs before and after treatment in two groups.3. Monitoring project Monitoring of Efficacy:Before and after treatment,monitoring the frequency of cough, cough symptoms integral, bronchial symptoms severity score (BSS) score, total points of TCM symptoms,Single symptom integral of TCM.Monitoring of safety by vital signs, blood routine, urine routine, electrocardiogram, hepatic function, and adverse events.4. The results and analysis method of statistics Statistic analysis would use the SPSS19.0 statistical analysis software for calculation. All statistical tests were two-sided, and when the P value was less than or equal to 0.05 would be considered to have the statistical significance.Results:1.Comparison of Cough episodes remission rate:There were significant difference between two groups before and after treatment, (P<0.05).The experimental group was better than control group.2. Comparison of Cough symptoms integral:There were significant difference between two groups before and after treatment, (P<0.05).The experimental group was better than control group.3. Comparison of BSS:There were significant difference between two groups before and after treatment, (P<0.05).The experimental group was better than control group.4. The total score of TCM symptoms:After treatment, the difference of statistically were significant including cure and effective rate, efficient and inefficient rate in two groups.5. The single symptom curative effect of TCM:There were significant difference between groups on the proportion of curative effect of main symptom including cough, cough up phlegm, evil wind symptoms in two groups after treatment, (P< 0.05).The experimental group was better than control group. There were no significant difference between the two groups in primary symptom of body heat, and secondary symptoms such as headache, stuffy nose, dry nose, runny nose, the sweat out, sore throat, dry throat, pharyngeal itching, pharyngeal congestion symptoms,(P>0.05).The curative effect of two groups has no difference.6. Adverse events The two groups had no serious adverse reactions.Conclusion:It is effectively that Maxing Shigan decoction combined with Zhisou powder in the treatment of acute bronchitis (syndrome of wind heat invading lung). The overall effect of this drug is better than Tai Chi in the syrup in this experiment.