Study On Chemical Constituents In Ansheng Dingzhi Ling

Children with attention deficit hyperactivity disorder is mainly manifested as attention is not focused, regardless of the occasion of hyperactivity and emotional impulses, and associated with cognitive disabilities and learning difficulties, is most common in children and adolescents mental disease of the nervous system. In recent years, the incidence is rising trend. Because of Western medicine in the treatment of adverse reactions, in the process of drug reduction, may produce clinical symptoms of rebound and affect the quality of sleep, and long-term medication will affect children’s growth and development, to the clinical use of drugs bring certain limitations, so more and more clinical researchers will study into the traditional Chinese medicine. Professor Han Xinmin according to clinical experience for many years. It is concluded that the hyperactivity of heart and liver fire syndrome is the main syndrome of hyperactivity, and development and study of the compound Anshen set Zhi Ling treatment. Chinese herbal compound in the previous analysis of the process using HPLC and HPTLC technology analysis, heavy workload, slow speed, control dependence is very high, and now appears UPLC-Orbitrap analysis speed is greatly improved, reduce labor intensity, under no control can also find more Anshen Ding Zhi Ling chemical composition. The the technology for more in-depth understanding of Anshen Zhi Ling of the pharmacodynamic material basis, to provide a basis for further study of compound monomer experimental. Objective:to in-depth understanding of Anshen Ding Zhi Ling compound water decocted liquid of chemical composition, and on this basis, further through and into the blood serum containing map comparison and analysis the constituents absorbed into blood. Methods:by consulting a large number of documents, making Anshen Ding Zhi Ling in each single herb medicine effective component database, using the UPLC-LTQ-Orbitrap ultra performance liquid phase-mass spectrometry instrument technology platform analysis the effective components of the molecular structure, and determine the source. Results:in this paper, we establish the Anshen Ding Zhi Ling Polyjuice Potion single pertain chemical literature database, including literature with the molecular formula, chemical name and other information, according to the database and standard atlas comparison identified 84 kinds of chemical components,25 of them as the prototype into the blood. To provide a basis for further clarifying what components of their therapeutic effects. Conclusion:using UPLC-LTQ-Orbitrap ultra performance liquid chromatography mass spectrometry analysis, initially identified Anshen Dingzhi Ling of pharmacodynamic material basis, and the content of baicalin was determined by UPLC for which components of the treatment to provide basis for further clearly.