Clinical Observation Of Dampness-eliminating And Stasis-removing And Collaterals-dredging Therapy For Preventing Deep Vein Thrombosis In Early Femoral Shaft Fracture Patients

Objectives:To explore the clinical effect and safety of therapy of eliminating dampness and removing stasis and dredging collaterals for preventing deep vein thrombosis (DVT) in early femoral shaft fracture patients.Methods:80 patients with femoral shaft fracture were equally randomized into the test group and the control group from February 2015 to February 2016. Both groups were hospitalized 14 days and accepted surgical treatment on day 4. Both groups were given the same comprehensive prevention program. Additionally, the test group was given QuShiHuaYuTongLuo prescription, a representative prescription for eliminating dampness and removing stasis and dredging collaterals. Serum D-dimer (D-D) and Hypersensitivity C-reactive protein(hs-CRP) as well as Hemorrheologic levels were examined in both groups on day 1,3,7 and 13 after surgery, while the color Doppler ultrasonography of the injured limb deep vein were measured on day 3,7 and 13.Results:According to the results of color Doppler ultrasonography of the injured limb deep vein, the test group had lower DVT incidence than the control group (P<0.05). On day 3,7 and 13, serum D-D and hs-CRP levels in test group were lower than that in the control group, and the difference were significant(P <0.05 or 0.01). On day 3, the hemorrheologic outcome (η bH200, η bL3, η p, HCT) in the test group differed from those in the control group (P<0.05 or 0.01). Compared with the control group, on day 7, the levels of ηbH200, ηbL3 and ηp in the test group were lower (P<0.01). On day 13, the levels of η bL3, η p and HCT were lower than the control group (P<0.05 or 0.01). Diarrhea occurred in 3 cases in the test group, and they got symptom relief after symptomatic treatment and completed the test successfully.Conclusion:The therapy of eliminating dampness and removing stasis and dredging collaterals can improve the blood fibrinolytic activity, relieve venous blood stasis and high viscosity state, reduce the levels of hs-CRP and prevent occurrence of DVT, which is safety and worthy of promotion and application.