Meta-analysis On The Effect Of VSD Combined With Free Skin Graft In The Treatment Of Large Area Skin Defect Comparing With Traditional Pressurized Packaging Technology

Objective:To assess the clinical effect of VSD combined with free skin graft in the treatment of large area skin defect comparing with traditional pressurized packaging technology.Methods:Systematic literature research of Cochrane Library,Pubmed,CNKI and Wanfang Database.We chose “negative pressure vaccum drainage ”,”free skin graft”,”large area skin defect” as keywords to search randomized controlled trials(RCTs))and controlled clinical trials(CCTs)of VSD combined with free skin graft versus traditional suppression of skin graft in the treatment of large area skin defect between Jan 2010 and Dec2015,and retrieved the references of the included literature to prevent leak investigation.The methodological quality of the ultimately included studies was assessed comprehensively,and meta-analysis was implemented using the Cochrane Collaboration’s software Rev Man5.2.Results:A total of 16 researches involved 1261 patients with large area skin defect,in the experimental group which included 715 patients,they take VSD negative pressure drainage technology combined with free skin graft,and the control group included 546 patients,they take traditional suppression of skin graft technology.A descriptive analysis of the results was presented: Compared with the skin graft survival,the experimental group and the control group had statistically significant difference 【 OR=7.77,95%CI(5.12,11.79),P<0.00001】,and the experimental group was better than the control group.Compared with infection rate,the experimental group and the control group had statistically significant difference【OR=0.10,95%CI(0.05,0.18),P<0.00001】,the experimental group was less than the control group.Compared with hospital days,the experimental group and the control group had statistically significant difference【OR=-15.89,95%CI(-17.08,-14.71),P<0.00001】,the experimental group was less than the control group.Conclusion:The results indicate that VSD negative pressure drainage technology combined with free skin graft in the treatment of large area skin defect can obviously improve the skin graft survival and reduce the infection rate and hospital days.