The Effect Of Aerobics Exercise And Transfer Factor Intervention On The Diabetic Rats’ Glucose Metabolism

Diabetes is glucose metabolism and endocrine disorders have a genetic predisposition, and then cause the body’s metabolic disorder clinical syndrome, its high incidence, severity caused great harm to human health. Research on treatment of diabetes through exercise is the choice of many scholars.Objective:Currently, the etiology and pathogenesis of diabetes has not been fully elucidated, the method of prevention the diabetes and its complications is still not perfect. This study intends to start from the exercise intervention and biological agents, to study its effect on the diabetic condition, the search for new ideas and a new target for the treatment of diabetes. At the same time, we have optimized the conditions for modeling diabetic animal models to explore the optimal conditions of diabetic rats.Methods:In this study, we made diabetic SD rats modeling by the method of streptozotocin. Using the method of aerobic exercise intervention, transfer factor intervention, and dual intervention, we study these effect on blood glucose, water intake, serum insulin, islet B cell function and thymus and spleen indexes like in diabetic rats.The results:1. The SD rats were fed high-fat diet, fasted 15h, using 35mg/kg STZ in traperitoneal injection can successfully establish a diabetic rat model, the success rate was 86.7%;2 Compared with normal rats, the diabetic control group of insulin secretion reduced, blood glucose increased, thymus and spleen atrophy, and there were significant differences in blood glucose, insulin, C peptide, thymus index, spleen index (P<0.01);3 compared with diabetic control rats, the rats blood glucose decreased significantly (P<0.01), insulin, C peptide, spleen index was significantly increased (P<0.01), thymus index increased (P<0.05) after six weeks of aerobic exercise.4 compared with the diabetic control group, transfer factor after six weeks intervention rats blood glucose significantly decreased (P<0.01), insulin levels (P<0.05), C peptide, spleen index and thymus index were significantly increased (P<0.01)5 After six weeks of double intervention, the intervention group of diabetic rats blood glucose decreased significantly (P<0.01), insulin, C peptide, thymus index, spleen index increased significantly (P<0.01).Conclusions:1. In the manufacture of diabetic rats, rats were fasted for an appropriate extension of time and increase the single intraperitoneal injection of streptozotocin dose can improve the success rate of modeling;2. Aerobic exercise and transfer factor can improve glucose metabolism in diabetic rats, maintain islet B cell function in rats, and promote insulin secretion, thereby causing blood sugar drops, and the double intervention is more obvious than a single intervention;3. Aerobic exercise and transfer factor can promote thymus and spleen of rats index, which enhances the immune system of rats, and the double intervention is more effective than a single intervention. With in-depth research on diabetes, diabetes prevention will also be further developed, therefore, molecular biology, gene expression and gene polymorphism and other aspects remains to be further studied.