The Preparation Of Nanomaterials Based On Copper Foam And The Application In Non-emzymatic Glucose Sensor

The detection of glucose has played an important role due to its practical applications in clinical diagnostics,food industry and biotechnology.Currently,glucose determination main depend on glucose biosensor base on glucose oxidase?GOD?in clinical diagnostics.However,glucose oxidase is a kind of protein,it suffer from some serious disadvantage such as temperature and pH,therefore,it is highly desired to design and develop non-enzymatic electrochemical glucose sensors based on direct electrocatalytic oxidation of glucose at an electrode surface.Transition metal copper is an ideal metal to fabricate enzymatic-free glucose sensors,and porous copper foam exhibits greater potential because of its large specific surface area.With the continuous development of nanotechnology in recent years,nano-sized copper and copper compounds have led to extensive research.The nanomaterials is grown on the three-dimensional porous copper foam substrate,and the porous substrate increases the active area,promotes electron transport on the electrode surface,combines the good physical and chemical properties of the nanostructured material,would further improve the sensitivity of the glucose sensor.In this paper,the morphology and structures of the three materials were analyzed by XRD,SEM and EDX.The electrochemical properties of the materials were investigated by cyclic voltammetry?CV?and chronoamperometry?I-t?.And the materials can be used for the determination of glucose in the true serum of the human body.The main contents of this paper are as follows:?1?Commercially available copper foam without any pretreatment was used as a 3D porous electrochemical sensing platform for nonenzymatic glucose detection,the sensor exhibits high performance towards glucose with the linear range from 1 mM to 0.5 mM,the sensitivity of 5.85 mAmM^-1cm^-2 and the detection limit of 0.5 mM?S/N=3?simultaneously.?2?We fabricated the hierarchical Cu/Cu?OH?₂ NRA/CF via a three-step strategy involving the wet chemical synthesis,chemical reduction and galvanostatic anodization.The hierarchical Cu/Cu?OH?₂ NRA/CF shows highly catalytic activity towards glucoseoxidation in an alkaline solution and be served as a promising electrode material for enzyme-free glucose sensing.At an applied potential of 0.5 V,the sensor showed a broad detection range of 1 ?M^-1.0 mM,a high sensitivity of 9.18 m AmM^-1 cm^-2,and a low detection limit of 0.45 ?M?S/N = 3?.?3?The CuS nanotubes grown on copper foam were prepared by self-sacrificial template method.The material was used as electrode for the oxidation of glucose,showed good catalytic activity.In 0.1 M NaOH solution,at low voltage of 0.45 V,a lower glucose concentration ranged from 1 ?M to 0.61 mM with high sensitivity of 8.66 mA mM^-1 cm^-2 and a higher glucose concentration ranged from 0.61 mM to 2.41 m M with relative low sensitivity of 2.42 mA mM^-1cm^-2and a low detection limit of 1 ?M?S/N = 3?.