Compound Sanchi Particle Clinical Investigaion In Treat Of Coronary Stable Angina Pectoris

Objective: By monitoring the blood lipid in patients with stable angina pectoris of coronary heart disease and serum hs-CRP, hepatic and renal functions, electrocardiogram and TCM symptom assessment, evaluation of angina, nitroglycerin stopped reducing rate, Seattle angina questionnaire scores and SF-12 changes in quality of life scores, compound 37 particles to improve stable angina pectoris of coronary heart disease.Methods: Select the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine in senile cardiovascular interal medcine in patients with stable angina pectoris of coronary heart disease Standards.25 cases were randomly divided into study group and control group. The control group were treated by isosorbide mononitrate, aspirin, atorvastatin calcuim, agina given sublingual nitroglycerin(adult 0.25-0.5mg/times, cycle once every 5 times until pain relief).Study group on the basis of control group were given 37 compound granules, that is,37 4grams,polygonum multiflorum 15 grams,danshen 15 grams,hawthorn 6 grams. One agent,in a matter of two oral. The treatment course is 4 weeks. The two groups were observed before treatment and after treatment in patients with serum lipid(TC,TG,LDL-C),serum hs-CRP, liver function(ALT, AST), kidney function(BUN, Cr), electrocardiogram. Recording patients' TCM symptom sore, angina pectoris integral, nitrolycerin stop poverty rate. Seatle angina questionnaire, the quality of life assessment. Using SPSS 17.0 statistical software for statistical analysis and draw conclusions.Results: 1.Compared with the control group, the study group patients TCM symptom sore, agina pectoris integral, nitroglycerin stop poverty rates have improved dramatically. Two groups of patients comparative differences are statistically significant(P<0.01;P<0.05). 2. Two groups of patients after treatment TC, TG, LDL, hs-CRP dose significantly lower than before, HDL levels increased, no significant changes in liver and kidney function. After the two groups were compared,research group TC,TG,LDL levels significantly lower than the control group, two groups of patients comparative differences are statistically significant(P<0.01;P<0.05). HDL levels increased significantly, two groups of patients comparative differences are statistically significant(P<0.01 or P<0.05).Hs-CRP levels were significantly reduced, two groups of patients comparative differences are statistically significant(P<0.01,P<0.05). ALT, AST, BUN, Cr no significant change(P>0.05). 3.Two groups of patients after treatment Seattle angina questionnaire,SF-12 Quality of life scale scores were elevated compared with before treatment. Patients in the study group Seattle angina questionnaire, SF-12 Quality of life scores were increased than the control group, two groups of patients comparative differences are statistically significant(P<0.01 or P<0.05).Conclusion: 1.37 compound granules combined with isosorbide mononitrateester, aspirin, atorvastatin calcium, angina sublingual nitroglycerin for clinical efficacy in patients with stable angina pectoris, nitroglycerin in patients with lower utilization rates. 2.37 compound granules combined with isosorbide mononitrate,aspirin,itorvastatin calcium treatment can improve patients' quality of life. 3.Integrated Chinese and Western treatment can significantly improve the stability of coronary heart disease and angina pectoris,but also to improve the quality of life in patients with positive.