The Relationship Of WHO Pathological Classification Of Thymoma With Maosaoka Clinical Stage And Myasthenia Gravis

objective : Discussion thymoma with myasthenia gravis in patients with WHO pathological classification(2004 WHO),Maosaoka clinical stage with myasthenia gravis clinical types,postoperative myasthenic crisis correlation between.Methods:Collected in May 2005 to December 2015 in the clinical and pathological data First Affiliated Hospital of Dalian Medical University,thoracic surgery resection line thymoma 250 cases of hospitalized patients were retrospectively analyzed,thymoma WHO pathological classification criteria used the latest version That 2004 WHO,WHO pathological type comparison thymoma with myasthenia gravis patients,Maosaoka MG clinical stage and clinical type,correlation between postoperative myasthenic crisis.The resulting data applications SPSS19.0 software for statistical analysis,taking P <0.05 as statistically significant.Results:(1)thymoma WHO pathological type,patients in this group A 24 cases(9.60%),AB-type 77 cases(30.80%),B1 type 32 cases(12.80%),B2-type 59 cases(49.17%),B3 type 51 cases(20.40%),C 7 cases(2.80%).thymoma with myasthenia gravis 120 cases(48.00%),wherein A 4 cases(3.34%),AB 33 cases(27.50%),B1 19 cases(15.83%),B2 31 cases(25.83%),B3 33 cases(27.50 %),C type 0 cases.Pathological type of thymoma and myasthenia gravis correlated(P <0.05),the difference was statistically significant,AB,B2,B3 thymoma easier with myasthenia gravis.(2)120 cases of thymoma with myasthenia gravis: ? of 56 cases(46.67%),? of 37 cases(30.83%),? 16 cases(13.33%),stage ? 11 cases(9.17%),and more in Masaoka?,? period;not thymoma with myasthenia gravis 130 cases: ? 21 cases(16.15%),? of 46 cases(35.38%),stage ? 51 cases(39.23%),? of 12 cases(9.24%),and more in ?,? period.Masaoka clinical stage thymoma with myasthenia gravis correlated(P <0.05).(3)The group of patients with pathology reportsshow accompanied by myasthenia gravis occurs mainly Masaoka?,? period.More malignant thymoma and Masaoka clinical stage,tumor prognosis worse,the greater the likelihood of recurrence.(4)thymoma 120 patients with myasthenia gravis,postoperative myasthenic crisis in 25 patients.Thymoma myasthenic crisis occurs more in Masaoka?,?,? period,? stage patients at most(40%).Thymoma patient pathology and postoperative myasthenic crisis occurs no significant correlation(P> 0.05),the difference was not statistically significant;between Masaoka clinical stage and postoperative myasthenic crisis occurs thymoma correlation(P <0.05),the difference was statistically significant.Clinical staging of thymoma later the more prone to myasthenic crisis.(5)The group of experiments showed that: A,AB,B1 majority of patients with Masaoka clinical stage ?,? stage,the prognosis is good,less recurrence;B2 thymoma with stage ?,? mainly;B3 thymoma in ?,? period-based,with some malignant behavior,poor prognosis,tumor metastasis likely.C thymoma to thymic carcinoma,and more at ? or ? stage.Conclusion: 1.pathological type thymoma and myasthenia gravis is closely related to the pathological type is AB,Type B thymoma patients with myasthenia gravis are more likely than other types of pathology patients,especially type B2.2.Masaoka clinical stage and is closely related to myasthenia gravis,thymoma ?,? stage with myasthenia gravis possibility of large,?,? of thymoma with myasthenia gravis less likely that the thymoma with myasthenia gravis clinical staging earlier.3.thymoma with myasthenia gravis postoperative myasthenic crisis and whether a type of thymoma Masaoka clinical stage correlation is obvious.Thymoma postoperative myasthenic crisis common in Masaoka?,?,? period,? of most patients.4.A,AB,B1 majority of patients with Masaoka clinical stage ?,? stage,the prognosis is good,less recurrence;B2 thymoma with stage ?,? mainly;B3 thymoma with stage ?,?-based,with some malignant tumor behavior and poor prognosis,the possibility of tumor metastasis is relatively large.C thymoma to thymic carcinoma,and more at ? or ? stage.Masaoka pathological type and clinicalstaging of thymoma,while applications for clinical diagnosis and surgical resection of myasthenia gravis prevention play a very important role.