| Purpose: Through summarizing literature and combining with the personal clinical practice,with the combination of Chinese and western medicine theory to explore,experiment,nourishing the liver bao soup summary and research for modern women within liver blood deficiency,liver and kidney after two virtual effect on reproductive endocrine and gonadal axis,from the serum hormone and ovarian tissue morphological changes confirmed that this is the formation of secondary ovarian one of the main causes of premature aging.Establishment of nourishing the liver bao soup to treat ovarian premature aging.Provide safe and effective clinical treatment of traditional Chinese medicine,small side effects of France?Method:Select the weight of 20 + 2 g,72 female kunming mice through weight selection method,divided randomly into blank control group,model control group,low dose group,Chinese medicine dose group,high dose group,positive control group,six groups of experiment,the six groups of female mice have been grouped tail suspension test mode,the blank control group not to build model,simulation of the women in the living environment formed by pressure of liver blood deficiency type ovarian premature aging,giving Chinese medicine treatment,nourishing the liver palace bao soup observation of traditional Chinese medicine for nourishing the liver palace bao soup ovarian premature aging model mice's serum hormone curative effect,discuss the therapeutic effect and mechanism of action.Result:By compared with model control group,low dose group,traditional Chinese medicine(TCM)in the dose group,high dose group,positive control group of female mice serum estradiol levels,in mature follicle stimulating hormone levels,luteinizing hormone content has a significant effect,low dose group,Chinese medicine dose group,high dose group,positive control group of traditional Chinese medicine can improve the premature aging mice serum levels of estradiol in the premature aging mice serum content of mature follicle stimulating hormone and luteinizing hormone,and the results show significant difference.After dosing,compared with model control group,low dose group,Chinese medicine in the dose group and high dose group in the serum estradiol levels increased significantly in mice,the results show that the traditional Chinese medicine(TCM)low doseimprove ovarian premature aging female mice serum estradiol in the proportion of 12%,Chinese medicine dose groups improve ovarian premature aging female mice serum estradiol in the proportion of 33%,Chinese medicine high dose group improve ovarian premature aging female mice serum estradiol in the proportion of 17%,positive control group in improving ovarian premature aging female mice serum estradiol in the proportion of 37%,the effect of the effect of dose group and positive control group a;Compared with model control group,low dose group,the dose and high dose group of mice in the serum luteinizing hormone content is significantly reduced,the calculation results show that,compared with model group,low dose to reduce the proportion is 42%,Chinese medicine Chinese medicine dose group by 57%,Chinese medicine high dose group was 50% lower,positive control group by 62%;Compared with model control group,low dose group,dose group and high dose group of mature follicle stimulating hormone levels in the serum of mice significantly reduced,the results show that the low dose by 47%,Chinese medicine Chinese medicine dose group of lower 6 Chinese medicine high dose group was 50% lower,positive control group was 70% lower.Experimental results show that the drug can significantly reduce ovarian premature aging female mice serum estradiol levels,improve the mice serum mature follicle stimulating hormone and luteinizing hormone levels,and have significant differences,including the dose effect is most obvious,can be used as a reference for the treatment of ovarian premature aging.Conclusion: The efficacy of nourishing the liver bao soup,Chinese medicine in combination with the practical significance of the obtained data,indicated that the herbal medicine has the effect of treatment of women ovarian senescence,and the effect is remarkable. |
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