Observation Of Ai'di-injection Combined With Docetaxel And Cisplation Chemotherapy In Treatment Of Advnced Non-small Cell Lung Cancer

Objective Through observing and comparing the difference of clinical symptoms?physical capacity?quality of 1ife?adverse reactions between Ai,di-injection combine with docetaxel and cisplation chemotherapy(the observation group)and only TP chemotherapy(the ontrol group)in the treatment of advanced non-small cell lung cancer(NSCLC),to discusse the influence of the Ai,di-injection on patients with advanced NSCLC treated with TP chemotherapy and furtherly provide the basis to apply the Ai,di-injection in clinic.Methods 73 patients firstly diognosed with non-small cell cancer in stage ?B or ?,whose average age were(58.79±8.06),were selected from December 2014 to December 2015,including 24 cases in stage ? B and 49 cases in stage ?,20 females and 53 males.Eligibility criteria were an Eastern Cooperative Oncology Group(ECOG)performance status of 0-2 or KPS score in more than 60 points,no contraindications for chemotherapy,nearly normal blood routine,coagulation function and liver and renal function before treament.We randomly divided the 73 patients into the control group(36 cases)and the observation group(37 cases).Therewas no significant difference in stage,sex and age(P>0.05).The control group received only TP chemotherapy.The observation group received Ai'di-injection during the TP chemotherapy.7 days were considered as a course of treatment,21 days for a chemotherapy cycle and 2 cycles for the observation node.Both two groups conventionally received the treatment of stomach protection(lansoprazole),liver protection(glycyrrhizin and glutathione),antiemetic(tropisetron)and leukocyte enhancement(recombinant human granulocyte colony-stimulating factor).Blood routine,liver function and renal function were tested at the day before the first cycle of chemotherapy and 7th day after the second cycle of chemotherapy to evaluate adverse reactions.Meanwhile,compare and assess the difference between two groups of scores in clinical symptoms?physical capacity and quality of 1ife.All datas were analyzed with SPSS 19.0 software.Results(1)Comparison in symptoms improvement:The chi-square test P values of two groups in positive rate of clinical symptoms were all greater than 0.05,revealing the comparability of two groups.After treatment,the improvement of symptom scores of the observation group,such as cough?fever?weakness?thirsty and sweating,was significantly higher than the control group,the difference was statistically significant(P<0.05).The other symptom scores of observation group were slightly higher than the control group,but there was no statistically significant difference between groups(P>0.05).(2)Comparison in physical capacity improvement:The P values of two groups before treament were higher than 0.05.After the treatment,two groups all enhanced KPS score significantly than before(P<0.01)and the KPS of theobservation group was significantly higher than that of control group(P<0.01).(3)Comparison in quality of life improvement:the difference of scores in all areas of the quality of life between two groups has no statistical significance before treament(P>0.05).The scores of symptoms as anorexia,nausea and vomiting,fatigue in control group after treatment were higher than that before treatment(P<0.05);The scores of role functioning,global health status,symptoms as loss of appetite,nausea and vomiting in observation group after treatment were higher than taht before(P<0.05),and the scores of symptoms as fatigue,shortness of breath,constipation were lower than that before treament(P<0.05);the scores of role functioning,global health status in observation group after treatment were higher than that of the control group(P<0.05),and the scores of symptoms as fatigue,shortness of breath,insomnia,constipation in observation group were lower than that of the control group(P<0.05).(4)Comparison in adverse reactions:the occurrence rate of observation group was significantly fewer than the control group in white blood cells dropping ? anemia(P <0.05).There was no significant difference between the two groups in the occurrence rate of thrombocytopenia?liver and renal function damage(P>0.05).Conclusion: Ai'di-injection combined with TP chemotherapy in the treatment of advanced non-small cell lung cancer,which can improve the clinical symptoms,enhance physical strength,improve the quality of life,reduce adverse reactions.