Effect Of Ginseng Red And Dredging Collaterals Granule On The Level Of VCAM-1,AS And Other Inflammatory Factors In Rabbits With Phlegm And Blood Stasis

Purpose: This topic is based on v evil under the guidance of the theory of phlegm and blood stasis,to explore the characteristics of traditional Chinese medicines by yiqi huoxue phlegm and red whether t2dm particles on coronary artery atherosclerosis hard phlegm stasis mutual junction have to prevent or reverse effects.Through experimental test and red t2dm particles of atherosclerosis,whether the blood lipid level and related.inflammatory molecules play a regulatory role,prove that Chinese medicine can indeed improve the atherosclerosis related indicators,so as to prevent or reverse the formation of atherosclerotic plaque,after the traditional Chinese medicine for the treatment of atherosclerosis.Method: Application high fat feed(1% cholesterol,8% egg yolk powder,5%lard and 89% common feed)and immune stimulation method AS rabbit model,for traditional Chinese medicine(TCM)and red t2dm particles(the main composition is: ginseng,rhodiola rosea,salvia miltiorrhiza,leech,Gua,fructus spikenard,dalbergiae stone calamus)therapeutic intervention,the of rabbit was observed after the AS plaque formation related inflammatory molecules in serum levels.Establish a male rabbit model of phlegm and blood stasis of atherosclerosis by each,were given drug treatment,detection and red t2dm Chinese traditional medicine granule on phlegm stasis of atherosclerosis by each male rabbit serum vascular cell adhesion molecule 1(VCAM1),intercellular adhesion molecule 1(ICAM 1),monocyte chemotaxis and rabbit aorta vascular cell adhesion molecule 1(VCAM1),intercellular adhesion molecule 1(ICAM 1),(nf-kappa B)protein phosphorylation nucleus factor and the level of gene expression.70 rabbits were randomly divided into 7 groups: blank control group,model group,aspirin joint simvastatin group,aspirin group in the control group,simvastatin group and control group,Chinese medicine group and the traditional Chinese medicine(TCM)prophylaxis and red t2dm particles drug treatment group.Adaptive feed after 1 week,observe its activities,such as waste after all did not appear abnormal,in addition to the blank control group at the fed to raise,the other groups are feeding high fat forage.Feeding time is 6 weeks,and analysis of rabbit carotid artery plaque formation.Again according to the above group for 6 weeks of treatment.After 6 weeks of treatment,detect each group of the change of blood lipid and related inflammatory molecules,comparing that traditional Chinese medicine(TCM)and red t2dm particles pulse who phlegm stasis mutual junction control.Result: After 12 weeks of treatment,and analysis of groups of cells related to molecular level,serum and carotid artery after comparison,through the software SPSS18.0 Student 's t test and variance analysis of the test group and model group differences were P < 0.05,proving that groups of data are statistically meaning effects on experimental rabbits.Among them,the traditional Chinese medicine(TCM)and red t2dm granule treatment dosage group of rabbit serum VCAM1,ICAM-1 and rabbit aorta VCAM1,ICAM-1,the nf-kappa B protein and gene expression decreased significantly;In group treated with traditional Chinese medicine(TCM)and red t2dm particles prevent contrast,except the joint simvastatin aspirin group(P > 0.05,group and other groups(P < 0.05 VCAM1,ICAM-1 in serum and rabbit aorta VCAM1,ICAM-1,the nf-kappa B protein and gene expression were significantly reduced in the other group.Conclusion: Confirm fu evil cause under the guidance of the theory,characteristics of traditional Chinese medicine(TCM)and red for t2dm particles AS has the very good prevention and curative effect,further illustrates the traditional Chinese medicine for the treatment of cardiovascular disease has important implications.AS for the future of the prevention,treatment,and further research provides the theoretical and experimental basis.