Aorui Gel In Treatment Of Reflux Esophagitis With Stagnated Heat In Liver And Stomach Syndrome Curative Effect Evaluation And Research On The Effects Of The Expression Of Ultramicro Na⁺-K⁺-ATPase And Ultramicro Ca²⁺-Mg

Objective: This study evaluated the Aorui Gel in treatment of reflux esophagitis with stagnated heat in liver and stomach syndrome therapeutic effect and healthy security by prospective double blind randomized controlled clinical design,to reveal the therapeutic mechanism of effect from the deeply molecular level.Methods: Qualified 60 cases of reflux esophagitis,according to the proportion of 1:1 randomly divided into treatment group and control group.At the same time two groups of taking omeprazole enteric capsules.The treatment group take Aorui Gel.The control group plus Aorui Gel simulation agent.4 weeks are a course.On the basis of clinical symptom score,rating under gastroscope and the change of the level of ultramicro Na⁺-K⁺-ATPase?uNaKATPase?and ultramicro Ca²⁺-Mg²⁺-ATPase?uCaMgATPase?,compared two groups of clinical effect and explore the mechanism of action of Aorui Gel.Laboratory blood routine,urine routine,liver function,renal function and so on to observe the security of Aorui Gel.Results: 1 The comparison in the two groups after treatment of gastroscope and symptoms integral difference was statistically significant?P?0.05?,indicating that the treatment group in improving patients of gastroscope performance and clinical symptoms are better than that in control group.2 The clinical curative effect of comprehensive classification comparison between the two groups : the treatment group cure rate was71.43%,and the total curative effect was 96.43%.The control group was 51.85% and 74.07%.There are differences between the two groups?P?0.05?,suggests that there is statistical significance,in comprehensive clinical curative effect of treatment group and control group.3 The levels of esophageal tissue uNaKATPase and uCaMgATPase difference between the two groups:the treatment group the levels of uNaKATPase and uCaMgATPase comparison before and after treatment was statistically significant?P?0.01?;Control group had no statistical significance?P> 0.05?;In the two groups after treatment the levels of uNaKATPase and uCaMgATPase comparison was statistically significant?P?0.05?.That indicated the treatment group the levels of uNaKATPase and uCaMgATPase increased significantly after treatment,the treatment group in improving the levels of uNaKATPase and uCaMgATPase is better than control group.4 The security comparion between the two groups: The two groups after the treatment,the blood routine,urine routine,liver function,renal function were no obvious abnormal,safety class 1 indicated that two groups of clinical drug application security.Conclusion: 1 Aorui Gel has the function of regulating vital energy,clearing heat,liver-discharging and stomach-harmonizing,lowering the adverse qi,can significantly improve clinical symptoms and under gastroscope manifestation of reflux esophagitis with stagnated heat in liver and stomach syndrome,and clinical use safety.2 Aorui Gel can improve the levels of esophageal tissue uNaKATPase and uCaMgATPase of reflux esophagitis with stagnated heat in liver and stomach syndrome,improve ability of LES pressure and peristalsis,so as to achieve the purpose of the treatment of reflux esophagitis.