Pharmaceutical Research Of Alkaloids Of Soghora Alopecuroides L.Double-layered Suppository

This study of Sophora alopecuroides L. extract is prepared into a double-layered suppository for treating inflammation of gynaecology. The preparation can prolong the retention time of the drug by the local vaginal administration and prolong the retention time of the drug by the slow release characteristic, thus ensuring the bioavailability of the drug, In order to provide a safe and effective new type of traditional Chinese medicine preparation for the treatment of gynecological inflammation.In this study, make full use of the unique advantages of vacuum dynamic extraction technology both low temperature and dynamic extraction, extraction technology of Sophora alopecuroides were studied. Orthogonal design was adopted to optimize the test, the optimal processing conditions for the effective parts of Sophora alopecuroides L.of coarse powder, and 12 times amount of water and 60 ? decompression and dynamic extraction 3 times, 1h each time. At the same time, through with the atmospheric pressure reflux method and boiling method more effective component yield, dry extract yield that decompression and dynamic extraction technology is used in edge extraction of Sophora alopecuroides L. Have adopted 732 cation exchange resin of Sophora alopecuroides L. extract was refined and purified, in order to improve the purity of alkaloids. Purification process conditions of effective parts of Sophora alopecuroides L:decompression concentration to the concentration of crude 1.Og/mL Sophora alopecuroides L. concentrated liquid, adding hydrochloric acid to regulate pH=3 732 type cation exchange resin, diameter ratio 10:1, static adsorption 2h,3.5BV of double distilled water is used for washing, the ammonia 5BV20% ammonia alcohol with 2BV/h flow rate of elution,collecting the eluted liquid, concentrated into thick paste, to 60 ? vacuum drying box drying is Sophora alopecuroides L.extract.According to the physical and chemical properties, the characteristics of vaginal delivery,This study is the Sophora alopecuroides L. total alkali extract is made into a double-layered suppository, the vaginal up long-term therapeutic effect. In accordance with the purpose of the use of mixed fatty acid glycerol ester to add some of the drug as the outer layer, with appearance, hardness, forming time and melt time limit for the evaluation index, the selection of water soluble matrix.The mixture of polyethylene glycol and polyethylene glycol is used as a drug carrier for inner layer, double-layered suppository were prepared according to the prescription by hot-melt method, and According to the Chinese Pharmacopoeia (2015 Edition) to evaluate the quality of the fourth general rules under the related preparation rules.