Objective Study On Traditional Chinese Medicine Differentiation Of Diabetic Deafness

ObjectiveResearch the specialties of course,body mass index(BMI),pure tone audiometry,acoustic immittance,fasting plasma glucose(FPG),glycosylated hemoglobin(HbAlc),blood lipid,fasting C peptide(C-P),hypersensitive c-reactive protein(HS-CRP),?2 microglo bulin(?2-MG),tumor necrosis factor ?(TNF-?),interleukin(IL-6),blood rheology diabetic deafness,and changes of these indicators in different syndrome types in diabetic deafness patients.In order to explore the differences and relations of index above between different syndrome types of diabetic deafness patients,and provides the theory basis for syndrome types,and the perfection of the microcosmic syndrome differentiation of traditional Chinese medicine system,provide appropriate point of traditional Chinese medicine and western medicine treatment of diabetic deafness.MethedsAll the cases in this study were selected from May,2015 to September,2016 in GuangDong NO.2 Hospital of Traditional Chinese Medicine,including simple diabetes group of 30 cases,132 cases of diabetic deafness group,all diabetic deafness cases were reassigned by TCM syndrome differentiation rule,including qi and yin deficiency group(38 cases),phlegm internal resistancegroup(33 cases),wet muddy resistance group(31cases),yin and yang deficiency group(30cases).Detailed medical history was recorded,including general information,tongue examination,pulse,symptoms,biochemical laboratory results,audiological examinations,and so on.Health control group(30 cases)was selected from the same period in medical center of GuangDong NO.2 Hospital of TCM which the biochemical laboratory indicators were normal,and no organic disease.The data were recorded in a special clinical observation table and Excel table,analysised with SPSS21.0 statistical software,P<0.05 was statistically significant.Results1.There is no difference between the incidence of men and women in Diabetic deafness and the onset average age of 64.85 years old.Compared with other groups,the age of Yin and Yang group is the oldest and the difference with statistical significance(P<0.05).2.The average diabetic duration of Diabetic deafness patients is 11 years,Compared with other groups,the diabetic duration of Yin and Yang group is the longest and the difference with statistical significance(P<0.05).3.The BMI result in three groups is:Diabetes deafness group>diabetes group>healthy control group,but there is no significant difference between diabetic deafness group and diabetes group(P>0.05).The difference is statistically significant between diabetes group and healthy control group(P<0.05).Compared with other syndromes,BMI in wet muddy resistance group is the highest among the three syndromes,and has significant differences between other syndromes.4.The levels of FBG and HbAlc in diabetes mellitus deafness group were higher than those in diabetic group,and the difference was statistically significant(P<0.05)between diabetes mellitus deafness group and diabetes mellitus group.The FBG result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>phlegm internal resistance group>qi and yin deficiency group,There are significant differences in the FBG among the syndromes of yin and yang deficiency group,wet muddy resistance group,phlegm stasis internal resistance group;The HbAlc result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>phlegm internal resistance group>qi and yin deficiency group,There are significant differences in the HbAlc among the syndromes of yin and yang deficiency group and other groups.5.The levels of F-C in diabetes mellitus deafness group were higher than those in diabetic group,and the difference was statistically significant(P<0.01)between diabetes mellitus deafness group and diabetes mellitus group.The F-C result in four syndromes is:yin and yang deficiency group<wet muddy resistance group<phlegm internal resistance group<qi and yin deficiency group,There is no significant difference in the F-C among all groups.6.The levels of HS-CRP,TNF-? and IL-6 in diabetic deafness patients are significantly higher than those in diabetes group and healthy control group(P<0.01,P<0.05).The HS-CRP result in four syndromes is:Yin and yang deficiency group>phlegm internal resistance group>wet muddy resistance group>qi and yin deficiency group,There are significant differences in F-C between yin and yang deficiency group and other three groups(P<0.01);The TNF-? result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>phlegm internal resistance group>qi and yin deficiency group,There are significant differences in TNF-a between yin and yang deficiency group and other three groups(P<0.01);The IL-6 result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>qi and yin deficiency group>phlegm internal resistance group,There are significant differences in TNF-a between yin and yang deficiency group and phlegm internal resistance group(P<0.05).7.The levels of ? 2-MG in diabetic deafness patients are significantly higher than those in diabetes group and healthy control group(P<0.01,P<0.05).The ?2-MG result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>qi and yin deficiency group>phlegm internal resistance group,There are significant differences among four syndromes except qi and yin deficiency group and phlegm internal resistance group.8.The levels of TCH,TG and LDL in diabetic deafness patients are significantly higher than those in diabetes group and healthy control group(P<0.01,P<0.05).The levels of HDL in diabetic deafness patients are lower without statistical significance.The TCH,TG and LDL result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>qi and yin deficiency group>phlegm internal resistance group,There are significant differences among four syndromes except wet muddy resistance group and phlegm internal resistance group(P<0.01 ? P<0.05).The HDL result in four syndromes is:yin and yang deficiency group<qi and yin deficiency group<phlegm internal resistance group<wet muddy resistance group.9.The levels of whole blood viscosity,plasma viscosity,erythrocyte rigidity index,erythrocyte aggregation index in diabetic deafness patients are significantly higher than those in diabetes group and healthy control group(P<0.01).The whole blood viscosity(200)result in four syndromes is:phlegm internal resistance group>qi and yin deficiency group>yin and yang deficiency group>wet muddy resistance group,There are significant differences among four syndromes except wet muddy resistance group and qi and yin deficiency group(P<0.01 ? P<0.05);The whole blood viscosity(30),the whole blood viscosity(1)result in four syndromes is:phlegm internal resistance group>qi and yin deficiency group>yin and yang deficiency group>wet muddy resistance group,There are significant differences among four syndromes(P<0.01 ? P<0.05);The whole blood viscosity(5)result in four syndromes is:phlegm internal resistance group>qi and yin deficiency group>yin and yang deficiency group>wet muddy resistance group,There are significant differences among four syndromes except yin and yang deficiency group and qi and yin deficiency group(P<0.01? P<0.05);The plasma viscosity result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>phlegm internal resistance group>qi and yin deficiency group,but without significant differences;The erythrocyte rigidity index,erythrocyte aggregation index result in four syndromes is:yin and yang deficiency group>wet muddy resistance group>phlegm internal resistance group>qi and yin deficiency group There are significant differences among four syndromes(P<0.01 ? P<0.05).10.Diabetic deafness hearing loss is mild,moderate,moderate to severe(84.1%)in general,very severe hearing loss is rare;Qi and yin deficiency group hearing loss are mainly mild,moderate(81.6%),wet muddy resistance group and phlegm internal resistance group hearing loss are mainly mild,moderate,moderate to severe hearing loss(90.9%,83.9%);yin and yang deficiency group hearing loss are moderate to severe and severe(80.0%);Hearing loss is more and more serious from the qi and yin deficiency to phlegm and internal resistance and wet muddy resistance,and then to the yin and yang.Conclusion1.The incidence of diabetic deafness has nothing to do with gender,the average age of onset of 65.48 years old,mainly in the elderly.Among all types of syndromes,yin and yang deficiency is the oldest.2.Diabetic deafness patients with an average duration of 11 years of diabetes,Diabetes more likely develops into deafness if the duration is longer.Yin and Yang deficiency has the longest course of disease,suggesting that the longer duration of diabetes in patients with deafness,the greater the possibility of developing yin and yang deficiency.3.Diabetic deafness patients with poor blood sugar control,islet dysfunction.With the progression of the disease,FBG and HbAlc is higher,fasting C-P is lower.4.Inflammatory markers are higher in diabetic deafness patients.The levels of HS-CRP,TNF-? and IL-6 in diabetic deafness were significantly higher than that in diabetes and healthy controls.With the progression of the disease,the levels of HS-CRP and TNF-? are higher and higher.5.Diabetic deafness has varying degrees of renal damage.Compared with diabetes and healthy control group,?2-MG increased in diabetic deafness.Compared with four syndromes,yang-yang deficiency group and the wet muddy resistance group ?2-MG were higher than other groups,and the kidney damage was heavier.6.Diabetic deafness patients with multiple obesity,and lipid metabolism disorders are severe than diabetes patients.Compared with different syndrome's BMI,we can see that the highest in wet dampness group.Compared with different syndromes lipids,we can see that in addition to HDL,the other indicators are getting higher and higher,lipid metabolic disorders become more serious.7.Diabetic deafness tend to hyperviscosity.Compared with different syndromes,the whole blood viscosity of dampness wet dampness group was the lowest,the highest was in phlegm stasis internal resistance group,and the plasma viscosity of different syndromes was not statistically different.Rigidity index and erythrocyte aggregation index increased gradually from qi and yin deficiency group to phlegm stasis internal resistance group and dampness middle resistance group to yin and yang deficiency group,which indicated that there are different degrees of blood in the whole development process of diabetic deafness rheological changes.8.Diabetic deafness hearing loss is mild,moderate,moderate to severe in general,very severe hearing loss is rare;Qi and yin deficiency group hearing loss are mainly mild,moderate,wet muddy resistance group and phlegm internal resistance group hearing loss are mainly mild,moderate,moderate to severe hearing loss;yin and yang deficiency group hearing loss are mainly moderate to severe and severe;Hearing loss is more and more serious from the qi and yin deficiency to phlegm and internal resistance and wet muddy resistance,and then to the yin and yang.